Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.61 |
| ▸ | PDE4A | P27815 | 9/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.61 |
| ▸ | PDE5A | O76074 | 2/20 | 0.61 |
| ▸ | PDE1A | P54750 | 1/20 | 0.61 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.61 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27472680 | 0.93 | PDE4D (0.68) | PDE4BPDE4DPDE4APDE4CPDE5A | |
| SCHEMBL4162765 | 0.89 | PDE5A (0.70) | PDE4BPDE4DPDE4APDE4CPDE5A | |
| SCHEMBL7910791 | 0.89 | ALDH1A1 (0.68) | PDE4BPDE4DPDE4APDE4CPDE5A | |
| SCHEMBL6881789 | 0.88 | PDE4D (0.60) | PDE4BPDE4DPDE4APDE4CPDE5A | |
| SCHEMBL7322708 | 0.87 | PDE4B (0.60) | PDE4BPDE4DPDE4APDE4CPDE5A | |
| SCHEMBL7907860 | 0.84 | PDE5A (0.67) | PDE4BPDE4DPDE4APDE4CPDE5A | |
| SCHEMBL7334102 | 0.83 | PDE4B (0.60) | PDE4BPDE4DPDE4APDE4CPDE5A | |
| SCHEMBL30009845 | 0.83 | PDE4B (0.80) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL1028427 | 0.83 | PDE4B (0.80) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL4728938 | 0.83 | PDE4B (0.80) | PDE4BPDE4DPDE4APDE4CMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626939-B1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2001-11-07 | — | — | EP | disclosed |