Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 5/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.32 |
| ▸ | CASR | P41180 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | EDNRB | P24530 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.31 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7322744 | 1.00 | NPSR1 (0.36) | NPSR1LMNAHCAR2KIF11HDAC4 | |
| SCHEMBL7322674 | 0.90 | SLC6A1 (0.38) | KIF11SLC6A1CASRMEN1CYP1A2 | |
| SCHEMBL7322679 | 0.90 | SLC6A1 (0.38) | KIF11SLC6A1CASRMEN1CYP1A2 | |
| SCHEMBL7319255 | 0.90 | SLC6A1 (0.38) | KIF11SLC6A1CASRMEN1CYP1A2 | |
| SCHEMBL7319245 | 0.90 | SLC6A1 (0.38) | KIF11SLC6A1CASRMEN1CYP1A2 | |
| SCHEMBL7326219 | 0.82 | KIF11 (0.39) | KIF11SLC6A1MEN1CYP1A2CYP2D6 | |
| SCHEMBL7326222 | 0.82 | KIF11 (0.39) | KIF11SLC6A1MEN1CYP1A2CYP2D6 | |
| SCHEMBL7320451 | 0.80 | KIF11 (0.40) | NPSR1LMNAHCAR2KIF11SLC6A1 | |
| SCHEMBL7322275 | 0.80 | KIF11 (0.40) | NPSR1LMNAHCAR2KIF11SLC6A1 | |
| SCHEMBL7312848 | 0.77 | KIF11 (0.41) | NPSR1LMNAKIF11CASRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999041227-A1 | TRICYCLIC COMPOUNDS AS GLYCINE TRANSPORT INHIBITORS | ALLELIX NEUROSCIENCE, INC. (US) | 1999-08-19 | — | — | WO | claimed |
| US-6162824-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ALLELIX NEUROSCIENCE INC. | 2000-12-19 | — | — | US | disclosed |
| WO-1999041227-A1 | TRICYCLIC COMPOUNDS AS GLYCINE TRANSPORT INHIBITORS | ALLELIX NEUROSCIENCE, INC. (US) | 1999-08-19 | — | — | WO | disclosed |