Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 15/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316770 | 0.82 | PDK2 (0.43) | PDK2ALDH1A1HSP90AA1TDP1MEN1 | |
| SCHEMBL7316176 | 0.82 | PDK2 (0.50) | PDK2LMNAHTTMAPTALDH1A1 | |
| SCHEMBL7322252 | 0.79 | PDK2 (0.60) | PDK2LMNAMAPTALDH1A1NPC1 | |
| SCHEMBL7323011 | 0.78 | PDK2 (0.53) | PDK2LMNAMAPTMEN1GAA | |
| SCHEMBL7315243 | 0.78 | PDK2 (0.41) | PDK2ALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL7320725 | 0.78 | PDK2 (0.51) | PDK2 | |
| SCHEMBL7315669 | 0.72 | PDK2 (0.39) | PDK2LMNAHTTPOLBMAPT | |
| SCHEMBL7315663 | 0.72 | PDK2 (0.39) | PDK2LMNAHTTPOLBMAPT | |
| SCHEMBL23655327 | 0.71 | PDK2 (0.61) | PDK2LMNAMAPTALDH1A1NPC1 | |
| SCHEMBL13128015 | 0.70 | PDK2 (1.00) | PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6162824-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ALLELIX NEUROSCIENCE INC. | 2000-12-19 | — | — | US | disclosed |