Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 14/20 | 0.51 |
| ▸ | ADAM17 | P78536 | 14/20 | 0.51 |
| ▸ | MMP9 | P14780 | 13/20 | 0.51 |
| ▸ | MMP1 | P03956 | 10/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324786 | 0.92 | MMP13 (0.52) | MMP13ADAM17MMP9MMP1CYP2C9 | |
| SCHEMBL7315991 | 0.90 | MMP13 (0.64) | MMP13ADAM17MMP9MMP1 | |
| SCHEMBL7314656 | 0.82 | MMP13 (0.57) | MMP13ADAM17MMP9MMP1 | |
| SCHEMBL7322743 | 0.82 | ALDH1A1 (0.39) | MMP13ADAM17MMP9MMP1CYP2C9 | |
| SCHEMBL7323855 | 0.82 | MMP13 (0.53) | MMP13ADAM17MMP9MMP1CYP2C9 | |
| SCHEMBL7320206 | 0.79 | MMP13 (0.50) | MMP13ADAM17MMP9MMP1CYP2C9 | |
| SCHEMBL7324779 | 0.76 | ALDH1A1 (0.38) | MMP13ADAM17MMP9MMP1CYP2C9 | |
| SCHEMBL7323692 | 0.76 | MMP13 (0.64) | MMP13ADAM17MMP9MMP1CYP2C9 | |
| SCHEMBL6816584 | 0.76 | ADAM17 (0.83) | MMP13ADAM17MMP9MMP1 | |
| SCHEMBL6815494 | 0.76 | ADAM17 (0.73) | MMP13ADAM17MMP9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938471-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2001-12-12 | — | — | EP | disclosed |
| EP-0938471-A1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | American Cyanamid Company (US) | 1999-09-01 | — | — | EP | disclosed |
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| WO-1998016503-A2 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |