Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 14/20 | 0.56 |
| ▸ | MME | P08473 | 3/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9068925 | 1.00 | ACE (0.56) | ACEMMECA1CA2 | |
| SCHEMBL27338453 | 0.88 | ACE (0.57) | ACEMMECA1CA2 | |
| SCHEMBL6163836 | 0.85 | MME (0.70) | ACEMME | |
| SCHEMBL547144 | 0.84 | KDM4E (0.58) | ACEMMECA1CA2 | |
| SCHEMBL9432921 | 0.84 | KDM4E (0.58) | ACEMMECA1CA2 | |
| SCHEMBL30232700 | 0.84 | KDM4E (0.58) | ACEMMECA1CA2 | |
| SCHEMBL27830772 | 0.84 | KDM4E (0.58) | ACEMMECA1CA2 | |
| SCHEMBL7323041 | 0.83 | MME (0.52) | ACEMMECA1CA2 | |
| SCHEMBL31355569 | 0.82 | CA2 (0.57) | ACEMMECA1CA2 | |
| SCHEMBL9068932 | 0.82 | MME (0.69) | ACEMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4401677-A | Enkephalinase inhibitors | E. R. SQUIBB & SONS, INC. (US) | 1983-08-30 | — | — | US | claimed |
| US-4339600-A | ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1982-07-13 | — | — | US | claimed |
| US-5496805-A | DIURETIC, HYPOTENSIVE | E. R. SQUIBB & SONS, INC. (US) | 1996-03-05 | — | — | US | disclosed |
| US-4474795-A | ANALGESICS, MERCAPTO-ALKANOYL AMINO ACIDS | E. R. SQUIBB & SONS, INC. (US) | 1984-10-02 | — | — | US | disclosed |
| US-4474799-A | Enkephalinase inhibitors | E. R. SQUIBB & SONS, INC. (US) | 1984-10-02 | — | — | US | disclosed |
| US-4401677-A | Enkephalinase inhibitors | E. R. SQUIBB & SONS, INC. (US) | 1983-08-30 | — | — | US | disclosed |
| US-4339600-A | ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1982-07-13 | — | — | US | disclosed |