Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17756302 | 1.00 | HDAC8 (0.42) | HDAC8DDB1CRBNTSHRHTT | |
| SCHEMBL2132300 | 0.81 | OPRM1 (0.39) | — | |
| SCHEMBL11605909 | 0.75 | TDP1 (0.50) | TSHRMAOBGRM2 | |
| SCHEMBL21461824 | 0.74 | TLR9 (0.40) | HDAC8DDB1CRBNTSHRHTT | |
| SCHEMBL25181453 | 0.72 | LMNA (0.43) | HDAC8DDB1CRBNGRM2 | |
| SCHEMBL9142562 | 0.72 | CYP3A4 (0.49) | HDAC8POLBGAA | |
| SCHEMBL8551693 | 0.72 | HDAC8 (0.41) | HDAC8DDB1CRBNTSHRHTT | |
| SCHEMBL15133186 | 0.72 | HDAC8 (0.41) | HDAC8DDB1CRBNTSHRHTT | |
| SCHEMBL1177522 | 0.72 | HDAC8 (0.41) | HDAC8DDB1CRBNTSHRHTT | |
| SCHEMBL7385157 | 0.69 | HDAC8 (0.47) | HDAC8DDB1CRBNGBA1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0964851-A1 | C-TERMINAL KETONE HYDROXAMIC ACID INHIBITORS OF MATRIX METALLOPROTEINASES AND TNFA SECRETION | Abbott Laboratories (US) | 1999-12-22 | — | — | EP | disclosed |
| US-5985911-A | COMBATTING DISEASE STATES INVOLVING TISSUE DEGENERATIVE PROCESSES I.E, RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR | ABBOTT LABORATORIES (US) | 1999-11-16 | — | — | US | disclosed |
| WO-1998030541-A1 | C-TERMINAL KETONE HYDROXAMIC ACID INHIBITORS OF MATRIX METALLOPROTEINASES AND TNFA SECRETION | ABBOTT LABORATORIES (US) | 1998-07-16 | — | — | WO | disclosed |