SCHEMBL7323173

SCHEMBL7323173

C#Cc1cc(C)c(NS(=O)(=O)c2ccc(OC)cc2)c(C(=O)OC)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 7/20 0.56
CYTH2 Q99418 1/20 0.56
GABRG2 P18507 1/20 0.55
GABRB3 P28472 1/20 0.55
GABRA3 P34903 1/20 0.55
LMNA P02545 4/20 0.53
CYP2C9 P11712 2/20 0.53
TSHR P16473 2/20 0.53
ALDH1A1 P00352 2/20 0.53
NPSR1 Q6W5P4 1/20 0.53
TCF4 P15884 1/20 0.48
CTNNB1 P35222 1/20 0.48
POLB P06746 1/20 0.47
PKM P14618 1/20 0.47
HPGD P15428 2/20 0.46
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
TP53 P04637 1/20 0.46
HTT P42858 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7308859 0.84 FFAR4 (0.74) FFAR4CYTH2GABRG2GABRB3GABRA3
SCHEMBL6810684 0.82 FFAR4 (0.60) FFAR4CYTH2GABRG2GABRB3GABRA3
SCHEMBL7320098 0.82 FFAR4 (0.60) FFAR4CYTH2GABRG2GABRB3GABRA3
SCHEMBL7315541 0.80 MTNR1A (0.40) CYTH2LMNATSHRALDH1A1POLB
SCHEMBL7316135 0.79 FFAR4 (0.57) FFAR4CYTH2GABRG2GABRB3GABRA3
SCHEMBL7320095 0.79 FFAR4 (0.56) FFAR4CYTH2GABRG2GABRB3GABRA3
SCHEMBL5159892 0.78 FFAR4 (0.74) FFAR4CYTH2GABRG2GABRB3GABRA3
SCHEMBL7324232 0.75 FFAR4 (0.51) FFAR4CYTH2GABRG2GABRB3GABRA3
SCHEMBL7319432 0.75 FFAR4 (0.59) FFAR4CYTH2GABRG2GABRB3GABRA3
SCHEMBL7315545 0.73 MMP13 (0.65)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0938471-B1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID CO (US) 2001-12-12 EP disclosed
EP-0938471-A1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS American Cyanamid Company (US) 1999-09-01 EP disclosed
US-5929097-A INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME AMERICAN CYANAMID COMPANY (US) 1999-07-27 US disclosed
WO-1998016503-A2 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID COMPANY (US) 1998-04-23 WO disclosed