SCHEMBL7324232

SCHEMBL7324232

COC(=O)c1cc(-c2cccs2)cc(C)c1NS(=O)(=O)c1ccc(OC)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 6/20 0.51
LMNA P02545 4/20 0.51
CYTH2 Q99418 1/20 0.51
TSHR P16473 2/20 0.50
HPGD P15428 2/20 0.50
GABRG2 P18507 1/20 0.50
GABRB3 P28472 1/20 0.50
GABRA3 P34903 1/20 0.50
ALDH1A1 P00352 3/20 0.48
CYP2C9 P11712 2/20 0.48
NPSR1 Q6W5P4 1/20 0.48
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
TCF4 P15884 1/20 0.47
CTNNB1 P35222 1/20 0.47
GAA P10253 1/20 0.46
MAPT P10636 1/20 0.45
L3MBTL1 Q9Y468 2/20 0.45
TP53 P04637 1/20 0.44
HTT P42858 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7320479 0.83 LMNA (0.51) FFAR4LMNACYTH2TSHRHPGD
SCHEMBL7308859 0.80 FFAR4 (0.74) FFAR4LMNACYTH2TSHRGABRG2
SCHEMBL7504285 0.78 MMP1 (0.38) LMNAHPGDGABRG2GABRB3GABRA3
SCHEMBL7321871 0.78 MAPT (0.37) LMNAALDH1A1MEN1KMT2AMAPT
SCHEMBL2119453 0.78 MEN1 (0.59) FFAR4LMNAGABRG2GABRB3GABRA3
SCHEMBL6810684 0.78 FFAR4 (0.60) FFAR4LMNACYTH2TSHRHPGD
SCHEMBL7320098 0.78 FFAR4 (0.60) FFAR4LMNACYTH2TSHRHPGD
SCHEMBL5159892 0.76 FFAR4 (0.74) FFAR4LMNACYTH2TSHRHPGD
SCHEMBL7316135 0.75 FFAR4 (0.57) FFAR4LMNACYTH2TSHRHPGD
SCHEMBL7323173 0.75 FFAR4 (0.56) FFAR4LMNACYTH2TSHRHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0938471-B1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID CO (US) 2001-12-12 EP disclosed
EP-0938471-A1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS American Cyanamid Company (US) 1999-09-01 EP disclosed
US-5929097-A INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME AMERICAN CYANAMID COMPANY (US) 1999-07-27 US disclosed
WO-1998016503-A2 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID COMPANY (US) 1998-04-23 WO disclosed