Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.56 |
| ▸ | METAP2 | P50579 | 2/20 | 0.56 |
| ▸ | METAP1 | P53582 | 2/20 | 0.56 |
| ▸ | BRD4 | O60885 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | CCR1 | P32246 | 1/20 | 0.47 |
| ▸ | CCR8 | P51685 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | MMP14 | P50281 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL317372 | 0.86 | KDM4E (0.49) | KDM4EMAPTLMNAHSP90AA1METAP2 | |
| SCHEMBL740289 | 0.82 | KDM4E (0.56) | KDM4EMAPTLMNAHSP90AA1METAP2 | |
| SCHEMBL27712289 | 0.82 | KDM4E (0.56) | KDM4EMAPTLMNAHSP90AA1METAP2 | |
| SCHEMBL29992757 | 0.80 | LRRK2 (0.46) | LMNAHSP90AA1L3MBTL1LRRK2TLR8 | |
| SCHEMBL3194949 | 0.79 | HSP90AA1 (0.56) | MAPTLMNAHSP90AA1ALDH1A1L3MBTL1 | |
| SCHEMBL3142508 | 0.79 | PSMD14 (0.56) | MAPTLMNAHSP90AA1ALDH1A1CCR1 | |
| SCHEMBL4608765 | 0.79 | LMNA (0.49) | KDM4EMAPTLMNAHSP90AA1METAP2 | |
| SCHEMBL20554409 | 0.79 | L3MBTL1 (0.56) | KDM4EMAPTLMNAHSP90AA1ALDH1A1 | |
| SCHEMBL29826020 | 0.79 | L3MBTL1 (0.56) | KDM4EMAPTLMNAHSP90AA1ALDH1A1 | |
| SCHEMBL29871808 | 0.79 | KMT2A (0.54) | KDM4EMAPTLMNAHSP90AA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4933447-A | FOR TREATMENT OF CARDIOVASCULAR DISORDERS | SS PHARMACEUTICAL CO., LTD. (JP) | 1990-06-12 | — | — | US | disclosed |
| EP-0308897-A1 | Quinoline derivatives | SS PHARMACEUTICAL CO., LTD. (JP) | 1989-03-29 | — | — | EP | disclosed |