Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.49 |
| ▸ | MMP2 | P08253 | 9/20 | 0.45 |
| ▸ | MMP8 | P22894 | 8/20 | 0.45 |
| ▸ | MMP12 | P39900 | 8/20 | 0.45 |
| ▸ | MMP13 | P45452 | 8/20 | 0.45 |
| ▸ | MMP14 | P50281 | 8/20 | 0.45 |
| ▸ | MMP16 | P51512 | 8/20 | 0.45 |
| ▸ | MMP9 | P14780 | 7/20 | 0.43 |
| ▸ | MMP3 | P08254 | 6/20 | 0.43 |
| ▸ | MMP1 | P03956 | 4/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323179 | 0.90 | KEAP1 (0.49) | KEAP1NFE2L2MMP2MMP8MMP12 | |
| SCHEMBL7317813 | 0.89 | MMP2 (0.49) | MMP2MMP8MMP12MMP13MMP14 | |
| SCHEMBL7317392 | 0.89 | KEAP1 (0.49) | KEAP1NFE2L2MMP2MMP8MMP12 | |
| SCHEMBL7323198 | 0.88 | MMP2 (0.44) | KEAP1NFE2L2MMP2MMP8MMP12 | |
| SCHEMBL7322110 | 0.85 | MMP2 (0.46) | KEAP1NFE2L2MMP2MMP8MMP12 | |
| SCHEMBL7321902 | 0.85 | MMP13 (0.56) | MMP2MMP8MMP12MMP13MMP14 | |
| SCHEMBL7317559 | 0.84 | CNR1 (0.46) | MMP2MMP8MMP12MMP13MMP14 | |
| SCHEMBL7321087 | 0.84 | HPGD (0.43) | KEAP1NFE2L2MMP2MMP8MMP12 | |
| SCHEMBL7317489 | 0.83 | KEAP1 (0.49) | KEAP1NFE2L2MMP2MMP8MMP12 | |
| SCHEMBL7324229 | 0.83 | MMP2 (0.44) | MMP2MMP8MMP12MMP13MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |