Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 5/20 | 0.66 |
| ▸ | MMP2 | P08253 | 3/20 | 0.57 |
| ▸ | MMP9 | P14780 | 3/20 | 0.57 |
| ▸ | CPB1 | P15086 | 1/20 | 0.55 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.55 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.54 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.54 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.54 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.54 |
| ▸ | MMP1 | P03956 | 1/20 | 0.52 |
| ▸ | MMP3 | P08254 | 1/20 | 0.52 |
| ▸ | MMP7 | P09237 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 1/20 | 0.52 |
| ▸ | ACE | P12821 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10770977 | 0.97 | FOLH1 (0.64) | FOLH1MMP2MMP9CPB1CPB2 | |
| SCHEMBL10772400 | 0.96 | FOLH1 (0.68) | FOLH1MMP2MMP9CPB1CPB2 | |
| SCHEMBL464715 | 0.85 | FOLH1 (0.78) | FOLH1MMP2MMP9CPB1CPB2 | |
| SCHEMBL4561005 | 0.85 | FOLH1 (0.78) | FOLH1MMP2MMP9CPB1CPB2 | |
| SCHEMBL806151 | 0.85 | FOLH1 (0.78) | FOLH1MMP2MMP9CPB1CPB2 | |
| SCHEMBL17646349 | 0.84 | TGM2 (0.51) | FOLH1MMP2MMP9ITGB3ITGA2B | |
| SCHEMBL19665781 | 0.84 | TGM2 (0.51) | FOLH1MMP2MMP9ITGB3ITGA2B | |
| SCHEMBL5775538 | 0.83 | PTGER4 (0.62) | FOLH1CPB1CPB2ITGB3ITGA2B | |
| SCHEMBL17646277 | 0.82 | F2 (0.49) | FOLH1MMP2MMP9ITGB3ITGA2B | |
| SCHEMBL464671 | 0.82 | FOLH1 (0.64) | FOLH1MMP2MMP9CPB1CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231919-B1 | N-HETEROCYCLIC ALCOHOL RENIN INHIBITORS | E.R. Squibb & Sons, Inc. (US) | 1993-01-20 | — | — | EP | disclosed |
| EP-0249445-A2 | Substituted aminoalkanoylaminoalkyl phosphonate angiotensin converting enzyme inhibitors | E.R. Squibb & Sons, Inc. (US) | 1987-12-16 | — | — | EP | disclosed |
| EP-0231919-A2 | N-Heterocyclic alcohol renin inhibitors | E.R. Squibb & Sons, Inc. (US) | 1987-08-12 | — | — | EP | disclosed |