SCHEMBL464671

SCHEMBL464671

O=C(NCCCCC(NC1CCC1NC(CCCCNC(=O)OCc1ccccc1)C(=O)O)C(=O)O)OCc1ccccc1

nearest known ligand 0.64

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
FOLH1 Q04609 6/20 0.64
MMP2 P08253 3/20 0.61
MMP9 P14780 3/20 0.61
ACE P12821 1/20 0.60
DPP8 Q6V1X1 2/20 0.56
DPP7 Q9UHL4 2/20 0.56
MMP1 P03956 1/20 0.56
MMP3 P08254 1/20 0.56
MMP7 P09237 1/20 0.56
MMP13 P45452 1/20 0.56
HTT P42858 1/20 0.54
CPB1 P15086 1/20 0.54
CPB2 Q96IY4 1/20 0.54
DPP4 P27487 1/20 0.53
DPP9 Q86TI2 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10772400 0.84 FOLH1 (0.68) FOLH1MMP2MMP9ACEMMP1
SCHEMBL15249558 0.84 FOLH1 (0.71) FOLH1MMP2MMP9MMP1MMP3
SCHEMBL4561005 0.84 FOLH1 (0.78) FOLH1MMP2MMP9CPB1CPB2
SCHEMBL464715 0.84 FOLH1 (0.78) FOLH1MMP2MMP9CPB1CPB2
SCHEMBL806151 0.84 FOLH1 (0.78) FOLH1MMP2MMP9CPB1CPB2
SCHEMBL25406900 0.84 FOLH1 (0.71) FOLH1MMP2MMP9MMP1MMP3
SCHEMBL31265517 0.83 FOLH1 (0.69) FOLH1MMP2MMP9MMP1MMP3
SCHEMBL13227705 0.83 FOLH1 (0.69) FOLH1MMP2MMP9MMP1MMP3
SCHEMBL31265519 0.83 FOLH1 (0.69) FOLH1MMP2MMP9MMP1MMP3
SCHEMBL7323375 0.82 FOLH1 (0.66) FOLH1MMP2MMP9ACEMMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9550860-B2 Cyclodextrin-based polymers for therapeutics delivery CERULEAN PHARMA INC. (US) 2017-01-24 US disclosed
US-20150165055-A1 CYCLODEXTRIN-BASED POLYMERS FOR DELIVERING THE THERAPEUTIC AGENTS COVALENTLY BOUND THERETO CERULEAN PHARMA INC. (US) 2015-06-18 US disclosed
US-20140288023-A1 CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY CERULEAN PHARMA INC. (US) 2014-09-25 US disclosed
US-8680202-B2 Cyclodextrin-based polymers for therapeutics delivery CERULEAN PHARMA INC. (US) 2014-03-25 US disclosed
US-20140044669-A1 CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY CERULEAN PHARMA INC. (US) 2014-02-13 US disclosed
US-8580244-B2 Cyclodextrin-based polymers for therapeutics delivery CERULEAN PHARMA INC. (US) 2013-11-12 US disclosed
US-8580243-B2 Cyclodextrin-based polymers for therapeutics delivery CERULEAN PHARMA INC. (US) 2013-11-12 US disclosed
US-8580242-B2 Cyclodextrin-based polymers for therapeutics delivery CERULEAN PHARMA INC. (US) 2013-11-12 US disclosed
US-8518388-B2 Cyclodextrin-based polymers for therapeutics delivery CERULEAN PHARMA INC. (US) 2013-08-27 US disclosed
US-20130203700-A1 CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY CERULEAN PHARMA INC. (US) 2013-08-08 US disclosed
US-20120301424-A1 CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY CERULEAN PHARMA INC. (US) 2012-11-29 US disclosed
US-8314230-B2 Cyclodextrin-based polymers for therapeutics delivery CERULEAN PHARMA INC. (US) 2012-11-20 US disclosed
US-20120289480-A1 CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY CERULEAN PHARMA INC. (US) 2012-11-15 US disclosed
US-20120283214-A1 CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY CERULEAN PHARMA INC. (US) 2012-11-08 US disclosed
US-8252276-B2 Cyclodextrin-based polymers for therapeutics delivery CERULEAN PHARMA INC. (US) 2012-08-28 US disclosed
US-20120178711-A1 CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY CERULEAN PHARMA INC. (US) 2012-07-12 US disclosed
US-20120065368-A1 CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY CERULEAN PHARMA INC. (US) 2012-03-15 US disclosed
US-8110179-B2 Cyclodextrin-based polymers for therapeutics delivery CERULEAN PHARMA INC. (US) 2012-02-07 US disclosed
US-20080058427-A1 Cyclodextrin-based polymers for therapeutics delivery INSERT THERAPEUTICS, INC. (US) 2008-03-06 US disclosed
US-7270808-B2 Having covalently coupled bioactive agent and targeting ligand; controlled release; stability, solubility; reduced toxicity INSERT THERAPEUTICS, INC. (US) 2007-09-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130203700-A1 CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY DDOST, DSC1, SI FOLH1 1091/4885MMP2 2876/4885MMP9 3322/4885
US-20120289480-A1 CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY DDOST, DSC1, SI FOLH1 1091/4885MMP2 2876/4885MMP9 3322/4885
US-20080058427-A1 Cyclodextrin-based polymers for therapeutics delivery DDOST, DSC1, SI FOLH1 1091/4885MMP2 2876/4885MMP9 3322/4885
US-20120178711-A1 CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY DDOST, DSC1, SI FOLH1 1091/4885MMP2 2876/4885MMP9 3322/4885
US-20120065368-A1 CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY DDOST, DSC1, SI FOLH1 1091/4885MMP2 2876/4885MMP9 3322/4885
US-20120283214-A1 CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY DDOST, DSC1, SI FOLH1 1091/4885MMP2 2876/4885MMP9 3322/4885
US-20140044669-A1 CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY DDOST, DSC1, SI FOLH1 1091/4885MMP2 2876/4885MMP9 3322/4885
US-20120301424-A1 CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY DDOST, DSC1, SI FOLH1 1091/4885MMP2 2876/4885MMP9 3322/4885
US-20140288023-A1 CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY DDOST, DSC1, SI FOLH1 1091/4885MMP2 2876/4885MMP9 3322/4885
US-20150165055-A1 CYCLODEXTRIN-BASED POLYMERS FOR DELIVERING THE THERAPEUTIC AGENTS COVALENTLY BOUND THERETO SDCBP, DDOST, CD47 FOLH1 1221/4885MMP2 3603/4885MMP9 4351/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.