Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 17/20 | 0.52 |
| ▸ | MMP13 | P45452 | 17/20 | 0.52 |
| ▸ | MMP1 | P03956 | 15/20 | 0.52 |
| ▸ | MMP12 | P39900 | 6/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 9/20 | 0.42 |
| ▸ | MMP2 | P08253 | 5/20 | 0.41 |
| ▸ | MMP8 | P22894 | 5/20 | 0.41 |
| ▸ | MMP14 | P50281 | 5/20 | 0.41 |
| ▸ | MMP16 | P51512 | 5/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323529 | 0.77 | MMP9 (0.43) | MMP9MMP13MMP1MMP12ADAM17 | |
| SCHEMBL7325108 | 0.76 | MMP13 (0.47) | MMP9MMP13MMP1MMP12ADAM17 | |
| SCHEMBL7322095 | 0.75 | MMP13 (0.51) | MMP9MMP13MMP1MMP12ADAM17 | |
| SCHEMBL5163025 | 0.72 | MMP13 (0.75) | MMP9MMP13MMP1MMP12ADAM17 | |
| SCHEMBL7318793 | 0.71 | MMP9 (0.53) | MMP9MMP13MMP1MMP12ADAM17 | |
| SCHEMBL7318177 | 0.70 | MMP13 (0.49) | MMP9MMP13MMP1MMP12ADAM17 | |
| SCHEMBL7319446 | 0.69 | MMP9 (0.49) | MMP9MMP13MMP1MMP12ADAM17 | |
| SCHEMBL6930709 | 0.69 | MMP13 (1.00) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL7323945 | 0.68 | MMP13 (0.56) | MMP9MMP13MMP1MMP12ADAM17 | |
| SCHEMBL7323949 | 0.68 | EGFR (0.44) | MMP9MMP13MMP1MMP12ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |