Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 8/20 | 0.53 |
| ▸ | MMP1 | P03956 | 7/20 | 0.53 |
| ▸ | MMP9 | P14780 | 7/20 | 0.53 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7509306 | 0.91 | MMP9 (0.54) | MMP13MMP1MMP9ADAM17CYP2C9 | |
| SCHEMBL7319849 | 0.91 | MMP9 (0.54) | MMP13MMP1MMP9ADAM17CYP2C9 | |
| SCHEMBL7316093 | 0.89 | MMP13 (0.69) | MMP13MMP1MMP9ADAM17 | |
| SCHEMBL7310943 | 0.85 | MMP9 (0.45) | MMP13MMP1MMP9ADAM17LMNA | |
| SCHEMBL7506542 | 0.85 | MMP9 (0.45) | MMP13MMP1MMP9ADAM17LMNA | |
| SCHEMBL27509927 | 0.83 | MMP13 (0.51) | MMP13MMP1MMP9ADAM17CYP2C9 | |
| SCHEMBL7553160 | 0.83 | MMP13 (0.55) | MMP13MMP1MMP9ADAM17CYP2C9 | |
| SCHEMBL7322413 | 0.83 | MMP13 (0.55) | MMP13MMP1MMP9ADAM17CYP2C9 | |
| SCHEMBL7504012 | 0.82 | MMP1 (0.45) | MMP13MMP1MMP9ADAM17PTGS2 | |
| SCHEMBL7323692 | 0.82 | MMP13 (0.64) | MMP13MMP1MMP9ADAM17CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938471-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2001-12-12 | — | — | EP | disclosed |
| EP-0938471-A1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | American Cyanamid Company (US) | 1999-09-01 | — | — | EP | disclosed |
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| WO-1998016503-A2 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |