Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 16/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | PKM | P14618 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.74 |
| ▸ | CNR1 | P21554 | 1/20 | 0.71 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.71 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.71 |
| ▸ | GABRP | O00591 | 1/20 | 0.52 |
| ▸ | GABRD | O14764 | 1/20 | 0.52 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.52 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.52 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.52 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.52 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.52 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.52 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29627864 | 1.00 | CHRM1 (1.00) | CHRM1ALDH1A1PKMHTTNPSR1 | |
| SCHEMBL7322165 | 0.89 | CHRM1 (0.80) | CHRM1ALDH1A1PKMHTTNPSR1 | |
| SCHEMBL7330628 | 0.85 | ALOX12 (1.00) | CHRM1ALDH1A1PKMHTTNPSR1 | |
| Nordazepam SCHEMBL31000330 | 0.83 | PDE4D (1.00) | CHRM1ALDH1A1PKMHTTNPSR1 | |
| Nordazepam SCHEMBL78453 | 0.83 | PDE4D (1.00) | CHRM1ALDH1A1PKMHTTNPSR1 | |
| Nordazepam SCHEMBL29354494 | 0.83 | PDE4D (1.00) | CHRM1ALDH1A1PKMHTTNPSR1 | |
| Nordazepam SCHEMBL8090999 | 0.83 | PDE4D (1.00) | CHRM1ALDH1A1PKMHTTNPSR1 | |
| SCHEMBL7323866 | 0.83 | CHRM1 (1.00) | CHRM1ALDH1A1PKMHTTNPSR1 | |
| SCHEMBL7331808 | 0.83 | CHRM1 (0.71) | CHRM1ALDH1A1PKMHTTNPSR1 | |
| SCHEMBL10741591 | 0.83 | CHRM1 (0.71) | CHRM1ALDH1A1PKMHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110579546-B | Method for measuring alprazolam tablet related substances by high performance liquid chromatography | 北京悦康科创医药科技股份有限公司 | 2022-05-03 | — | — | CN | claimed |
| CN-110579546-A | Method for measuring alprazolam tablet related substances by high performance liquid chromatography | 北京悦康科创医药科技股份有限公司 | 2019-12-17 | — | — | CN | claimed |
| CN-110579546-B | Method for measuring alprazolam tablet related substances by high performance liquid chromatography | 北京悦康科创医药科技股份有限公司 | 2022-05-03 | — | — | CN | disclosed |
| CN-113549078-A | Preparation method of stable isotope labeled alprazolam and estazolam internal standard reagent | 谱同生物医药科技(常州)有限公司 | 2021-10-26 | — | — | CN | disclosed |
| US-11021448-B2 | 1,3-dihydro-1,4-benzodiazepine-2-thiones for the treatment of CNS related diseases | HOFFMANN-LA ROCHE INC. (US) | 2021-06-01 | — | — | US | disclosed |
| CN-110579546-A | Method for measuring alprazolam tablet related substances by high performance liquid chromatography | 北京悦康科创医药科技股份有限公司 | 2019-12-17 | — | — | CN | disclosed |
| EP-3535253-A1 | 1,3-DIHYDRO-1,4-BENZODIAZEPINE-2-THIONES FOR THE TREATMENT OF CNS RELATED DISEASES | H. Hoffnabb-La Roche Ag (CH) | 2019-09-11 | — | — | EP | disclosed |
| US-20190256478-A1 | 1,3-DIHYDRO-1,4-BENZODIAZEPINE-2-THIONES FOR THE TREATMENT OF CNS RELATED DISEASES | HOFFMANN-LA ROCHE INC. (US) | 2019-08-22 | — | — | US | disclosed |
| US-8106189-B2 | Process for preparation of triazol-benzodiazepine derivatives | CENTAUR CHEMICALS PVT LTD (IN) | 2012-01-31 | — | — | US | disclosed |
| US-20090093629-A1 | PROCESS FOR PREPARATION OF TRIAZOL-BENZODIAZEPINE DERIVATIVES | CENTAUR CHEMICALS PVT LTD (IN) | 2009-04-09 | — | — | US | disclosed |
| US-20090093629-A1 | PROCESS FOR PREPARATION OF TRIAZOL-BENZODIAZEPINE DERIVATIVES | CENTAUR CHEMICALS PVT LTD (IN) | 2009-04-09 | — | — | US | disclosed |
| US-4116956-A | BENZODIAZEPINE DERIVATIVES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1978-09-26 | — | — | US | disclosed |
| US-4094870-A | 2-Substituted thio-1,4-benzodiazepine derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JA) | 1978-06-13 | — | — | US | disclosed |
| US-4021441-A | 1-[(Allylamino)-methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines | THE UPJOHN COMPANY (US) | 1977-05-03 | — | — | US | disclosed |
| US-4012413-A | 1-(2-AMINOALKYL)-6-PHENYL-TRIAZOLO-BENZODIAZEPINE COMPOUNDS USED AS TRANQUILIZERS AND ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1977-03-15 | — | — | US | disclosed |
| US-4010177-A | [3-Substituted-5-[(di-methylamino)methyl]-4H-1,2,4-triazol-4-yl]benzophenones and process | THE UPJOHN COMPANY (US) | 1977-03-01 | — | — | US | disclosed |
| US-4005099-A | 1-[(Dimethylamino)-methyl]-6-aryl-4H-imidazo[1,5-a][1,4]benzodiazepines | THE UPJOHN COMPANY (US) | 1977-01-25 | — | — | US | disclosed |
| US-3992408-A | CHEMICAL INTERMEDIATES | THE UPJOHN COMPANY (US) | 1976-11-16 | — | — | US | disclosed |
| US-3987052-A | SEDATIVES, TRANQUILIZERS, MUSCLE RELAXANTS | THE UPJOHN COMPANY (US) | 1976-10-19 | — | — | US | disclosed |
| US-3980789-A | SOPORIFICS AND SLEEP INDUCERS | THE UPJOHN COMPANY (US) | 1976-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093629-A1 | PROCESS FOR PREPARATION OF TRIAZOL-BENZODIAZEPINE DERIVATIVES | GABBR1, GABBR2, CYP2C19 | CHRM1 1016/4885ALDH1A1 2973/4885PKM 114/4885 |
| US-11021448-B2 | 1,3-dihydro-1,4-benzodiazepine-2-thiones for the treatment of CNS related diseases | CHRM1, CHRM2, CHRM4 | CHRM1 1/4885ALDH1A1 1148/4885PKM 1164/4885 |
| US-20190256478-A1 | 1,3-DIHYDRO-1,4-BENZODIAZEPINE-2-THIONES FOR THE TREATMENT OF CNS RELATED DISEASES | CHRM1, CHRM2, CHRM4 | CHRM1 1/4885ALDH1A1 1148/4885PKM 1164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.