Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 9/20 | 0.56 |
| ▸ | MMP1 | P03956 | 8/20 | 0.56 |
| ▸ | MMP9 | P14780 | 8/20 | 0.56 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.47 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7314362 | 0.87 | MMP13 (0.52) | MMP13MMP1MMP9ADAM17CYP2C9 | |
| SCHEMBL7317778 | 0.84 | MMP13 (0.66) | MMP13MMP1MMP9ADAM17CYP2C9 | |
| SCHEMBL7323519 | 0.83 | MMP9 (0.49) | MMP13MMP1MMP9ADAM17CYP2C9 | |
| SCHEMBL6810778 | 0.80 | MMP9 (0.81) | MMP13MMP1MMP9ADAM17CYP2C9 | |
| SCHEMBL7324074 | 0.79 | HTT (0.48) | MMP13MMP1CYP2C9LMNAKEAP1 | |
| SCHEMBL7323855 | 0.78 | MMP13 (0.53) | MMP13MMP1MMP9ADAM17CYP2C9 | |
| SCHEMBL7553160 | 0.78 | MMP13 (0.55) | MMP13MMP1MMP9ADAM17CYP2C9 | |
| SCHEMBL7322413 | 0.78 | MMP13 (0.55) | MMP13MMP1MMP9ADAM17CYP2C9 | |
| SCHEMBL7311624 | 0.78 | CYP2C9 (0.60) | MMP13MMP1MMP9ADAM17CYP2C9 | |
| SCHEMBL7322108 | 0.78 | MMP13 (0.55) | MMP13MMP1MMP9ADAM17LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938471-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2001-12-12 | — | — | EP | disclosed |
| CN-1240429-A | Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors | AMERICAN CYANAMID CO (US) | 2000-01-05 | — | — | CN | disclosed |
| EP-0938471-A1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | American Cyanamid Company (US) | 1999-09-01 | — | — | EP | disclosed |
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| WO-1998016503-A2 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |