SCHEMBL7322108

SCHEMBL7322108

COc1ccc(S(=O)(=O)N(C)c2c(C)cc(CCc3ccc(-c4ccccc4)cc3)cc2C(=O)O)cc1

nearest known ligand 0.55

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MMP13 P45452 6/20 0.55
MMP9 P14780 5/20 0.55
MMP1 P03956 5/20 0.55
ADAM17 P78536 4/20 0.55
LMNA P02545 2/20 0.49
STAT3 P40763 1/20 0.48
BMP1 P13497 1/20 0.48
TAS2R14 Q9NYV8 4/20 0.47
PDE4D Q08499 1/20 0.47
PTPN22 Q9Y2R2 1/20 0.47
PTGES O14684 1/20 0.46
TAS2R8 Q9NYW2 1/20 0.46
CXCR3 P49682 1/20 0.46
KEAP1 Q14145 3/20 0.46
NFE2L2 Q16236 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7322292 0.91 MMP13 (0.68) MMP13MMP9MMP1ADAM17
SCHEMBL7323855 0.83 MMP13 (0.53) MMP13MMP9MMP1ADAM17TAS2R14
SCHEMBL7320206 0.82 MMP13 (0.50) MMP13MMP9MMP1ADAM17STAT3
SCHEMBL7323692 0.81 MMP13 (0.64) MMP13MMP9MMP1ADAM17KEAP1
SCHEMBL7322103 0.81 MMP1 (0.44) MMP13MMP9MMP1STAT3BMP1
SCHEMBL7324075 0.78 MMP13 (0.56) MMP13MMP9MMP1ADAM17LMNA
SCHEMBL7324723 0.77 MMP13 (0.47) MMP13MMP9MMP1ADAM17TAS2R14
SCHEMBL7355097 0.75 MMP1 (0.56) MMP13MMP9MMP1ADAM17LMNA
SCHEMBL7322284 0.75 MMP13 (0.52) MMP13MMP9MMP1ADAM17BMP1
SCHEMBL7313984 0.74 MMP13 (0.51) MMP13MMP9MMP1ADAM17

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0938471-B1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID CO (US) 2001-12-12 EP disclosed
EP-0938471-A1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS American Cyanamid Company (US) 1999-09-01 EP disclosed
US-5929097-A INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME AMERICAN CYANAMID COMPANY (US) 1999-07-27 US disclosed
WO-1998016503-A2 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID COMPANY (US) 1998-04-23 WO disclosed