Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.62 |
| ▸ | MIF | P14174 | 1/20 | 0.60 |
| ▸ | FLT3 | P36888 | 3/20 | 0.56 |
| ▸ | CDK2 | P24941 | 2/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.55 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.55 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.55 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.55 |
| ▸ | CDK9 | P50750 | 1/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.55 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.55 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 4/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.50 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.50 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | LYN | P07948 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2650330 | 0.81 | FLT3 (0.74) | MIFFLT3DYRK1ADYRK1BKDR | |
| SCHEMBL29109646 | 0.81 | FLT3 (0.69) | MIFFLT3DYRK1ADYRK1BKDR | |
| SCHEMBL30655418 | 0.81 | FLT3 (0.69) | MIFFLT3DYRK1ADYRK1BKDR | |
| SCHEMBL14138786 | 0.81 | MIF (0.60) | MIFFLT3CDK2DYRK1ADYRK1B | |
| SCHEMBL73445 | 0.81 | MIF (0.60) | MIFFLT3CDK2DYRK1ADYRK1B | |
| SCHEMBL25789350 | 0.79 | MIF (0.57) | MIFFLT3DYRK1ADYRK1BKDR | |
| SCHEMBL14098511 | 0.78 | MIF (0.56) | MIFFLT3CDK2DYRK1ADYRK1B | |
| SCHEMBL16675756 | 0.78 | MIF (0.59) | MIFFLT3FYNCHEK1 | |
| SCHEMBL18003003 | 0.78 | MIF (0.56) | MIFFLT3CDK2DYRK1ADYRK1B | |
| SCHEMBL72363 | 0.78 | IRAK4 (0.61) | MIFFLT3CDK2DYRK1ADYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8131527-B1 | FGFR pharmacophore compounds | ASTEX THERAPEUTICS LTD. (GB) | 2012-03-06 | — | — | US | disclosed |
| US-8131527-B1 | FGFR pharmacophore compounds | ASTEX THERAPEUTICS LTD. (GB) | 2012-03-06 | — | — | US | disclosed |
| US-8131527-B1 | FGFR pharmacophore compounds | ASTEX THERAPEUTICS LTD. (GB) | 2012-03-06 | — | — | US | disclosed |