Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | LTA4H | P09960 | 1/20 | 0.55 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | BCHE | P06276 | 4/20 | 0.49 |
| ▸ | ACHE | P22303 | 4/20 | 0.49 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.49 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.49 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324364 | 0.90 | HRH3 (0.59) | PPARAALDH1A1KDM4EMEN1NPC1 | |
| SCHEMBL7449615 | 0.90 | HPGD (0.54) | PPARAALDH1A1MEN1NPC1KMT2A | |
| SCHEMBL7331294 | 0.87 | NPC1 (0.57) | ALDH1A1KDM4ENPC1LTA4HHPGD | |
| SCHEMBL7326393 | 0.87 | HRH3 (0.53) | ALDH1A1KDM4ENPC1LTA4HHPGD | |
| SCHEMBL7327514 | 0.81 | LTA4H (0.52) | NPC1LTA4HHPGDPSMB1PSMB5 | |
| SCHEMBL7328905 | 0.79 | KDM4E (0.53) | ALDH1A1KDM4EMEN1NPC1KMT2A | |
| SCHEMBL13305513 | 0.78 | HRH2 (0.66) | ALDH1A1KDM4ELTA4HHRH4HRH2 | |
| SCHEMBL13305536 | 0.76 | LTA4H (0.66) | ALDH1A1KDM4ELTA4HHRH4PSMB1 | |
| SCHEMBL11937419 | 0.74 | KDM4E (0.95) | ALDH1A1KDM4ENPC1LTA4HHRH4 | |
| SCHEMBL11015160 | 0.74 | PPARA (1.00) | PPARAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674514-A1 | USE OF ARYLOXYALKYL SUBSTITUTED CYCLIC AMINES AS CALCIUM CHANNEL ANTAGONISTS AND NEW PHENYLOXYALKYL PIPERIDIN DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994013291-A1 | USE OF ARYLOXYALKYL SUBSTITUTED CYCLIC AMINES AS CALCIUM CHANNEL ANTAGONISTS AND NEW PHENYLOXYALKYL PIPERIDIN DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1994-06-23 | — | — | WO | disclosed |