Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.50 |
| ▸ | ESR1 | P03372 | 6/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324866 | 0.90 | PPARA (0.58) | ABCB1PPARANPC1MEN1KMT2A | |
| SCHEMBL7449615 | 0.81 | HPGD (0.54) | HRH3PPARANPC1MEN1KMT2A | |
| SCHEMBL7331294 | 0.80 | NPC1 (0.57) | HRH3NPC1KDM4EALDH1A1HPGD | |
| SCHEMBL7326393 | 0.80 | HRH3 (0.53) | HRH3NPC1KDM4EALDH1A1HPGD | |
| SCHEMBL7328905 | 0.78 | KDM4E (0.53) | HRH3NPC1MEN1KMT2AKDM4E | |
| SCHEMBL22536963 | 0.76 | LMNA (0.55) | HRH3PPARAKMT2ALMNAMAPK1 | |
| SCHEMBL11015218 | 0.76 | PPARA (0.78) | HRH3PPARAKMT2ASMN1; SMN2LMNA | |
| SCHEMBL7374421 | 0.74 | HRH3 (1.00) | HRH3ABCB1ESR1KDM4EALDH1A1 | |
| SCHEMBL7324359 | 0.74 | HCRTR1 (0.54) | HRH3ABCB1NPC1ALDH1A1HPGD | |
| SCHEMBL7327514 | 0.74 | LTA4H (0.52) | HRH3NPC1HPGDRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674514-A1 | USE OF ARYLOXYALKYL SUBSTITUTED CYCLIC AMINES AS CALCIUM CHANNEL ANTAGONISTS AND NEW PHENYLOXYALKYL PIPERIDIN DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994013291-A1 | USE OF ARYLOXYALKYL SUBSTITUTED CYCLIC AMINES AS CALCIUM CHANNEL ANTAGONISTS AND NEW PHENYLOXYALKYL PIPERIDIN DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1994-06-23 | — | — | WO | disclosed |