Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.46 |
| ▸ | CDC25B | P30305 | 2/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6719502 | 0.84 | CTNNB1 (0.59) | KMT2AALDH1A1HPGDCDC25BTACR1 | |
| SCHEMBL12419177 | 0.82 | EPHX1 (0.48) | KMT2AALDH1A1EPHX1SLC1A3SLC1A2 | |
| SCHEMBL8083878 | 0.82 | SLC1A3 (0.52) | KMT2AALDH1A1EPHX1SLC1A3SLC1A2 | |
| SCHEMBL7322093 | 0.81 | CTNNB1 (0.60) | KMT2AALDH1A1HPGDSLC1A3SLC1A2 | |
| SCHEMBL18671842 | 0.81 | EPHX1 (0.47) | KMT2AALDH1A1HPGDEPHX1SLC1A3 | |
| SCHEMBL1045002 | 0.80 | ALDH1A1 (0.50) | KMT2AALDH1A1HPGDCDC25BKDM4E | |
| SCHEMBL6589138 | 0.80 | CTNNB1 (0.55) | KMT2AALDH1A1HPGDCDC25BTACR1 | |
| SCHEMBL10966205 | 0.79 | EPHX2 (0.47) | KMT2AALDH1A1HPGDMEN1MAPT | |
| SCHEMBL27320801 | 0.79 | EPHX2 (0.47) | KMT2AALDH1A1HPGDTDP1MAPT | |
| SCHEMBL13821887 | 0.78 | EPHX2 (0.51) | KMT2AALDH1A1HPGDCDC25BTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1046525-C | Compounds containing a fused bicyclic ring and processes therefor | BRISTOL MYERS SQUIBB CO (US) | 1999-11-17 | — | — | CN | disclosed |
| CN-1099392-A | Compounds containing a fused bicyclic ring and processes therefor | BRISTOL MYERS SQIBB COMPANY (US) | 1995-03-01 | — | — | CN | disclosed |
| US-5262436-A | Administering; enzyme inhibitor | SCHERING CORPORATION (US) | 1993-11-16 | — | — | US | disclosed |
| EP-0566157-A1 | Neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1993-10-20 | — | — | EP | disclosed |
| US-5061710-A | Atrial natriuretic factors | SCHERING CORPORATION (US) | 1991-10-29 | — | — | US | disclosed |
| US-4929641-A | DIURETICS, ANGIOTENSIN CONVERTING ENZYMES | SCHERING CORPORATION (US) | 1990-05-29 | — | — | US | disclosed |
| US-4801609-A | Mercapto-acylamino acid antihypertensives | SCHERING CORPORATION (US) | 1989-01-31 | — | — | US | disclosed |
| EP-0254032-A2 | Neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1988-01-27 | — | — | EP | disclosed |