Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 4/20 | 0.83 |
| ▸ | CTSV | O60911 | 3/20 | 0.70 |
| ▸ | CTSL | P07711 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.67 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.64 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.64 |
| ▸ | KIF11 | P52732 | 1/20 | 0.63 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.58 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.58 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.58 |
| ▸ | FBP1 | P09467 | 1/20 | 0.57 |
| ▸ | MYC | P01106 | 1/20 | 0.54 |
| ▸ | MAX | P61244 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1463066 | 0.87 | GRIK1 (0.84) | MPOCTSVCTSLMAPTMEN1 | |
| SCHEMBL4249335 | 0.86 | CTSV (0.71) | MPOCTSVCTSLMAPTMEN1 | |
| SCHEMBL354532 | 0.83 | CTSV (1.00) | CTSVCTSLMAPTMEN1KMT2A | |
| SCHEMBL5344962 | 0.81 | CTSV (0.76) | MPOCTSVCTSLMAPTMEN1 | |
| SCHEMBL3026731 | 0.81 | CTSV (0.76) | MPOCTSVCTSLMAPTMEN1 | |
| SCHEMBL3028534 | 0.81 | CTSV (0.76) | MPOCTSVCTSLMAPTMEN1 | |
| SCHEMBL23691075 | 0.81 | MPO (0.76) | MPOMEN1KMT2AGRIK1AKR1C3 | |
| SCHEMBL31207343 | 0.81 | MPO (0.61) | MPOCTSVCTSLMAPTMEN1 | |
| SCHEMBL21068140 | 0.81 | MPO (0.61) | MPOCTSVCTSLMAPTMEN1 | |
| SCHEMBL21068139 | 0.81 | MPO (0.61) | MPOCTSVCTSLMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5674863-A | BENZODIAZEPINEDIONE DERIVATIVE; FIBRINOGIN BINDING INHIBITOR | GENENTECH, INC. (US) | 1997-10-07 | — | — | US | disclosed |
| US-5674865-A | BENZODIAZEPINEDIONE DERIVATIVE; FIBRINOGIN BINDING INHIBITOR | GENENTECH, INC. (US) | 1997-10-07 | — | — | US | disclosed |
| US-5663166-A | ANTICOAGULANTS OF 1,4-BENZODIAZEPINE-2,5-DIONE AND 2-BENZOAZEPINE-1,4-DIONE DERIVATIVES; PREVENTS FIBRINOGEN BINDING NECESSARY FOR PLATELET AGGREGATION; SIDE EFFECT REDUCTION, E.G. EXCESSIVE BLEEDING | GENENTECH, INC. (US) | 1997-09-02 | — | — | US | disclosed |
| US-5565449-A | PLATELET AGGREGATION INHIBITORS | GENENTECH, INC. (US) | 1996-10-15 | — | — | US | disclosed |
| EP-0610334-B1 | NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII B III A RECEPTOR | GENENTECH INC (US) | 1996-01-24 | — | — | EP | disclosed |
| EP-0610334-A1 | NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII b?III a? RECEPTOR. | GENENTECH INC (US) | 1994-08-17 | — | — | EP | disclosed |
| WO-1993008174-A1 | NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPIIbIIIa RECEPTOR | GENENTECH, INC. (US) | 1993-04-29 | — | — | WO | disclosed |