SCHEMBL7325277

SCHEMBL7325277

COc1ccc(S(=O)(=O)N(Cc2ccccc2)c2cccc(C)c2C(=O)O)cc1

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP13 P45452 8/20 0.81
MMP9 P14780 7/20 0.81
MMP1 P03956 7/20 0.81
LMNA P02545 3/20 0.60
ALDH1A1 P00352 1/20 0.60
NPSR1 Q6W5P4 1/20 0.60
MEN1 O00255 1/20 0.57
KMT2A Q03164 1/20 0.57
NR3C1 P04150 1/20 0.57
PGR P06401 1/20 0.57
TAS2R14 Q9NYV8 2/20 0.56
PTGES O14684 1/20 0.56
TAS2R8 Q9NYW2 1/20 0.56
CXCR3 P49682 1/20 0.56
MMP12 P39900 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.54
ADAM17 P78536 1/20 0.54
KEAP1 Q14145 1/20 0.54
NFE2L2 Q16236 1/20 0.54
MAPT P10636 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7313498 0.89 MMP9 (1.00) MMP13MMP9MMP1MMP12ADAM17
SCHEMBL7314690 0.89 MMP13 (0.74) MMP13MMP9MMP1LMNAALDH1A1
SCHEMBL7322409 0.85 MMP9 (0.66) MMP13MMP9MMP1LMNAALDH1A1
SCHEMBL7453335 0.85 MMP9 (0.68) MMP13MMP9MMP1LMNAALDH1A1
SCHEMBL27404001 0.83 MMP13 (0.60) MMP13MMP9MMP1LMNAALDH1A1
SCHEMBL7313461 0.82 MMP13 (0.81) MMP13MMP9MMP1LMNAALDH1A1
SCHEMBL27569110 0.81 MMP13 (0.70) MMP13MMP9MMP1LMNAALDH1A1
SCHEMBL7318559 0.80 MMP13 (0.83) MMP13MMP9MMP1LMNAALDH1A1
SCHEMBL7321854 0.80 MMP9 (0.84) MMP13MMP9MMP1LMNAALDH1A1
SCHEMBL7417553 0.80 MMP9 (0.56) MMP13MMP9MMP1LMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0938471-B1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID CO (US) 2001-12-12 EP disclosed
CN-1240429-A Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors AMERICAN CYANAMID CO (US) 2000-01-05 CN disclosed
EP-0938471-A1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS American Cyanamid Company (US) 1999-09-01 EP disclosed
US-5929097-A INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME AMERICAN CYANAMID COMPANY (US) 1999-07-27 US disclosed
WO-1998016503-A2 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID COMPANY (US) 1998-04-23 WO disclosed