Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 11/20 | 0.49 |
| ▸ | MMP12 | P39900 | 10/20 | 0.49 |
| ▸ | MMP9 | P14780 | 9/20 | 0.49 |
| ▸ | MMP8 | P22894 | 8/20 | 0.49 |
| ▸ | MMP13 | P45452 | 8/20 | 0.49 |
| ▸ | MMP14 | P50281 | 8/20 | 0.49 |
| ▸ | MMP16 | P51512 | 8/20 | 0.49 |
| ▸ | MMP3 | P08254 | 6/20 | 0.49 |
| ▸ | MMP1 | P03956 | 5/20 | 0.49 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.41 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7313502 | 0.91 | MMP13 (0.52) | MMP2MMP12MMP9MMP8MMP13 | |
| SCHEMBL7314697 | 0.89 | MMP2 (0.45) | MMP2MMP12MMP9MMP8MMP13 | |
| SCHEMBL7313468 | 0.83 | MMP2 (0.49) | MMP2MMP12MMP9MMP8MMP13 | |
| SCHEMBL7322659 | 0.82 | MMP2 (0.47) | MMP2MMP12MMP9MMP8MMP13 | |
| SCHEMBL7316266 | 0.81 | MMP2 (0.52) | MMP2MMP12MMP9MMP8MMP13 | |
| SCHEMBL7317813 | 0.81 | MMP2 (0.49) | MMP2MMP12MMP9MMP8MMP13 | |
| SCHEMBL7318564 | 0.81 | MMP2 (0.49) | MMP2MMP12MMP9MMP8MMP13 | |
| SCHEMBL7351236 | 0.80 | MMP2 (0.48) | MMP2MMP12MMP9MMP8MMP13 | |
| SCHEMBL7322985 | 0.80 | MMP2 (0.45) | MMP2MMP12MMP9MMP8MMP13 | |
| SCHEMBL7322414 | 0.80 | TP53 (0.45) | MMP2MMP12MMP9MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |