Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 8/20 | 0.45 |
| ▸ | MMP8 | P22894 | 7/20 | 0.45 |
| ▸ | MMP12 | P39900 | 7/20 | 0.45 |
| ▸ | MMP13 | P45452 | 7/20 | 0.45 |
| ▸ | MMP14 | P50281 | 7/20 | 0.45 |
| ▸ | MMP16 | P51512 | 7/20 | 0.45 |
| ▸ | MMP9 | P14780 | 6/20 | 0.43 |
| ▸ | MMP3 | P08254 | 5/20 | 0.43 |
| ▸ | MMP1 | P03956 | 4/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7325283 | 0.89 | MMP2 (0.49) | MMP2MMP8MMP12MMP13MMP14 | |
| SCHEMBL7313502 | 0.86 | MMP13 (0.52) | MMP2MMP8MMP12MMP13MMP14 | |
| SCHEMBL7323179 | 0.85 | KEAP1 (0.49) | MMP2MMP8MMP12MMP13MMP14 | |
| SCHEMBL7323308 | 0.83 | KEAP1 (0.49) | MMP2MMP8MMP12MMP13MMP14 | |
| SCHEMBL7317392 | 0.83 | KEAP1 (0.49) | MMP2MMP8MMP12MMP13MMP14 | |
| SCHEMBL7323420 | 0.82 | NPC1 (0.43) | MMP2MMP8MMP12MMP13MMP14 | |
| SCHEMBL7317489 | 0.82 | KEAP1 (0.49) | MMP2MMP8MMP12MMP13MMP14 | |
| SCHEMBL7313468 | 0.77 | MMP2 (0.49) | MMP2MMP8MMP12MMP13MMP14 | |
| SCHEMBL7323621 | 0.77 | NAMPT (0.44) | MMP2MMP13MMP9MMP3MMP1 | |
| SCHEMBL7323198 | 0.76 | MMP2 (0.44) | MMP2MMP8MMP12MMP13MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |