SCHEMBL7325520

SCHEMBL7325520

CCOC(=O)CCN1CC(=O)N(c2ccccc2)c2ccc(CCCCCNC(=O)OC(C)(C)C)cc2C1=O

nearest known ligand 0.41

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TPSAB1 Q15661 1/20 0.41
TPSD1 Q9BZJ3 1/20 0.41
TPSG1 Q9NRR2 1/20 0.41
SIGMAR1 Q99720 2/20 0.40
PDCD1 Q15116 1/20 0.39
CD274 Q9NZQ7 1/20 0.39
NAMPT P43490 2/20 0.39
DRD2 P14416 5/20 0.37
NPSR1 Q6W5P4 1/20 0.36
BRD4 O60885 1/20 0.36
NPC1L1 Q9UHC9 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
FAAH O00519 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7331158 0.93 DRD2 (0.39) TPSAB1TPSD1TPSG1SIGMAR1PDCD1
SCHEMBL7330041 0.93 DRD2 (0.39) TPSAB1TPSD1TPSG1SIGMAR1PDCD1
SCHEMBL7334083 0.92 TPSAB1 (0.37) TPSAB1TPSD1TPSG1SIGMAR1NAMPT
SCHEMBL7326364 0.92 TPSAB1 (0.37) TPSAB1TPSD1TPSG1SIGMAR1NAMPT
SCHEMBL7333421 0.88 TPSAB1 (0.40) TPSAB1TPSD1TPSG1SIGMAR1PDCD1
SCHEMBL7327440 0.88 TPSAB1 (0.40) TPSAB1TPSD1TPSG1SIGMAR1PDCD1
SCHEMBL7325740 0.87 SIGMAR1 (0.39) TPSAB1TPSD1TPSG1SIGMAR1PDCD1
SCHEMBL7330496 0.86 TPSAB1 (0.39) TPSAB1TPSD1TPSG1SIGMAR1PDCD1
SCHEMBL7331215 0.86 TPSAB1 (0.39) TPSAB1TPSD1TPSG1SIGMAR1PDCD1
SCHEMBL7335699 0.85 PDCD1 (0.38) TPSAB1TPSD1TPSG1SIGMAR1PDCD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5674863-A BENZODIAZEPINEDIONE DERIVATIVE; FIBRINOGIN BINDING INHIBITOR GENENTECH, INC. (US) 1997-10-07 US disclosed
US-5674865-A BENZODIAZEPINEDIONE DERIVATIVE; FIBRINOGIN BINDING INHIBITOR GENENTECH, INC. (US) 1997-10-07 US disclosed
US-5663166-A ANTICOAGULANTS OF 1,4-BENZODIAZEPINE-2,5-DIONE AND 2-BENZOAZEPINE-1,4-DIONE DERIVATIVES; PREVENTS FIBRINOGEN BINDING NECESSARY FOR PLATELET AGGREGATION; SIDE EFFECT REDUCTION, E.G. EXCESSIVE BLEEDING GENENTECH, INC. (US) 1997-09-02 US disclosed
US-5565449-A PLATELET AGGREGATION INHIBITORS GENENTECH, INC. (US) 1996-10-15 US disclosed
EP-0610334-B1 NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII B III A RECEPTOR GENENTECH INC (US) 1996-01-24 EP disclosed
EP-0610334-A1 NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII b?III a? RECEPTOR. GENENTECH INC (US) 1994-08-17 EP disclosed
WO-1993008174-A1 NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPIIbIIIa RECEPTOR GENENTECH, INC. (US) 1993-04-29 WO disclosed