Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6499135 | 0.82 | CYP2C19 (0.44) | CYP2C19HSD17B10LMNAKDM4EXDH | |
| SCHEMBL5870589 | 0.76 | CYP2C19 (0.65) | CYP2C19HSD17B10LMNAGABRR1KDM4E | |
| SCHEMBL5870372 | 0.75 | CYP2C19 (0.44) | CYP2C19HSD17B10LMNAGABRR1KDM4E | |
| Hydrochloric Acid SCHEMBL5869997 | 0.75 | CYP2C19 (0.62) | CYP2C19HSD17B10LMNAGABRR1KDM4E | |
| SCHEMBL2101530 | 0.72 | LMNA (0.45) | CYP2C19HSD17B10LMNAKDM4EHRH3 | |
| SCHEMBL5870375 | 0.72 | SMN1; SMN2 (0.42) | CYP2C19HSD17B10LMNAKDM4ETDP1 | |
| SCHEMBL5870445 | 0.71 | KDM4E (0.58) | HSD17B10LMNAKDM4EGAASMN1; SMN2 | |
| SCHEMBL5870451 | 0.71 | HPGD (0.41) | CYP2C19HSD17B10KDM4EGAASMN1; SMN2 | |
| SCHEMBL6500732 | 0.69 | CYP2C19 (0.46) | CYP2C19HSD17B10LMNAGABRR1KDM4E | |
| SCHEMBL14692540 | 0.68 | CYP2C19 (0.57) | CYP2C19HSD17B10LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0242973-B1 | INDOLE DERIVATIVES, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1991-07-17 | — | — | EP | disclosed |