Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7330529 | 0.89 | KDM4E (0.48) | GAAKDM4EKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7331892 | 0.87 | TSHR (0.49) | GAAKDM4EKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7335424 | 0.85 | KMT2A (0.42) | GAAPKMKDM4EKMT2AMEN1 | |
| SCHEMBL7334780 | 0.85 | MEN1 (0.40) | KMT2AMEN1SMN1; SMN2L3MBTL1POLB | |
| SCHEMBL7334149 | 0.85 | PTGDR2 (0.44) | GAAKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7324003 | 0.83 | KDM4E (0.50) | GAAKDM4EKMT2ASMN1; SMN2POLB | |
| SCHEMBL7332002 | 0.77 | ALDH1A1 (0.47) | KMT2AMEN1ALDH1A1LMNA | |
| Fumaric Acid SCHEMBL7325579 | 0.74 | GAA (0.55) | GAAPKMKDM4EKMT2AMEN1 | |
| Fumaric Acid SCHEMBL7325589 | 0.72 | GAA (0.55) | GAAPKMKDM4EKMT2AMEN1 | |
| SCHEMBL7333021 | 0.72 | GPBAR1 (0.34) | KMT2AMEN1SMN1; SMN2POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376624-B1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMA CO LTD (JP) | 1994-09-14 | — | — | EP | disclosed |
| US-4977175-A | GASTROINTESTINAL DISORDERS, ANTIEMETICS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1990-12-11 | — | — | US | disclosed |
| EP-0376624-A1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1990-07-04 | — | — | EP | disclosed |