Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7331892 | 0.91 | TSHR (0.49) | KDM4ESMN1; SMN2LMNAKMT2ATSHR | |
| SCHEMBL7325586 | 0.89 | GAA (0.53) | KDM4ESMN1; SMN2LMNAKMT2ATSHR | |
| SCHEMBL7335424 | 0.88 | KMT2A (0.42) | KDM4ESMN1; SMN2LMNAKMT2AALOX15 | |
| SCHEMBL7324003 | 0.88 | KDM4E (0.50) | KDM4ESMN1; SMN2LMNAKMT2ATSHR | |
| SCHEMBL7332002 | 0.87 | ALDH1A1 (0.47) | LMNAKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL7334780 | 0.87 | MEN1 (0.40) | SMN1; SMN2LMNAKMT2ATSHRALDH1A1 | |
| SCHEMBL7334149 | 0.84 | PTGDR2 (0.44) | SMN1; SMN2KMT2AALDH1A1MEN1GAA | |
| SCHEMBL7333021 | 0.81 | GPBAR1 (0.34) | SMN1; SMN2LMNAKMT2AALDH1A1MEN1 | |
| Fumaric Acid SCHEMBL7354752 | 0.77 | KDM4E (0.48) | KDM4ESMN1; SMN2ACHEBACE1LMNA | |
| Fumaric Acid SCHEMBL7354754 | 0.77 | KDM4E (0.48) | KDM4ESMN1; SMN2ACHEBACE1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376624-B1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMA CO LTD (JP) | 1994-09-14 | — | — | EP | disclosed |