Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 2/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 3/20 | 0.33 |
| ▸ | TTK | P33981 | 3/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388124 | 0.82 | CTSL (0.48) | PDE4APDE4BPDE4CPDE4DCHRM3 | |
| Hydrochloric Acid SCHEMBL7023573 | 0.81 | CTSL (0.47) | PDE4APDE4BPDE4CPDE4DCHRM3 | |
| SCHEMBL1387953 | 0.81 | CTSL (0.47) | PDE4APDE4BPDE4CPDE4DCHRM3 | |
| Hydrochloric Acid SCHEMBL7028301 | 0.80 | CTSL (0.46) | PDE4APDE4BPDE4CPDE4DCHRM3 | |
| SCHEMBL1388167 | 0.79 | CHRM3 (0.40) | PDE4APDE4BPDE4CPDE4DCHRM3 | |
| Hydrochloric Acid SCHEMBL7029936 | 0.78 | CHRM3 (0.39) | PDE4APDE4BPDE4CPDE4DCHRM3 | |
| SCHEMBL6155689 | 0.76 | NUDT1 (0.40) | MEN1KMT2AKDM4EALDH1A1CYP3A4 | |
| SCHEMBL8396714 | 0.74 | CTSL (0.37) | PDE4APDE4BPDE4CPDE4DCHRM3 | |
| SCHEMBL8978402 | 0.69 | ADORA1 (0.37) | CTSLCTSBADORA3AURKBCYP3A4 | |
| SCHEMBL5964495 | 0.67 | CTSL (0.47) | PDE4APDE4BPDE4CPDE4DCHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0916673-A1 | 6-Amino purine derivatives having PDE-IV inhibition activity | Euroceltique S.A. (LU) | 1999-05-19 | — | — | EP | disclosed |
| EP-0916672-A1 | 6-Amino purine derivatives having PDE-IV inhibition activity and intermediates | Euroceltique S.A. (LU) | 1999-05-19 | — | — | EP | disclosed |
| WO-1995000516-A1 | NOVEL CHEMICAL COMPOUNDS HAVING PDE-IV INHIBITION ACTIVITY | EURO-CELTIQUE S.A. (LU) | 1995-01-05 | — | — | WO | disclosed |