SCHEMBL7321964

SCHEMBL7321964

CCCCCN1CCC(CCOc2ccc(Cl)cc2)CC1

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 13/20 0.64
SIGMAR1 Q99720 3/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL27431543 0.99 SIGMAR1 (0.64) HRH3SIGMAR1
SCHEMBL7324710 0.88 HRH3 (0.51) HRH3SIGMAR1
SCHEMBL7323805 0.88 MEN1 (0.60) HRH3SIGMAR1
Hydrochloric Acid SCHEMBL7326809 0.87 SIGMAR1 (0.49) HRH3SIGMAR1
Hydrochloric Acid SCHEMBL9532080 0.87 MAPK1 (0.52) HRH3SIGMAR1
SCHEMBL7317615 0.87 ALDH1A1 (0.59) HRH3SIGMAR1
SCHEMBL7322566 0.87 TMEM97 (0.61) HRH3SIGMAR1
SCHEMBL7325971 0.86 KDM4E (0.60) HRH3SIGMAR1
Hydrochloric Acid SCHEMBL7322101 0.86 MEN1 (0.59) HRH3SIGMAR1
SCHEMBL7326091 0.86 HRH3 (0.67) HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1992002502-A1 N-HYDROCARBYL-4-SUBSTITUTED PIPERIDINES, THEIR PREPARATION AND USE AS CALCIUM BLOCKING AGENTS SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1992-02-20 WO disclosed