Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359187 | 0.85 | KMT2A (0.58) | NPC1RAB9AALDH1A1CNR1MEN1 | |
| SCHEMBL7360125 | 0.85 | NPC1 (0.55) | NPC1RAB9AALDH1A1CNR1MEN1 | |
| SCHEMBL7335367 | 0.83 | NPC1 (0.55) | NPC1RAB9AALDH1A1CNR1HDAC1 | |
| SCHEMBL7356345 | 0.81 | NPC1 (0.65) | NPC1RAB9AHDAC1HDAC2 | |
| SCHEMBL7326215 | 0.80 | CYP3A4 (0.67) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL7175921 | 0.80 | PLAAT3 (0.54) | MEN1KMT2AHDAC1HDAC2ATM | |
| SCHEMBL7331861 | 0.80 | PLAAT3 (0.57) | ALDH1A1HDAC1HDAC2ATMSMN1; SMN2 | |
| SCHEMBL7355959 | 0.78 | HDAC1 (0.54) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL18760165 | 0.77 | NPC1 (0.67) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9782076 | 0.76 | SLC2A1 (0.65) | ALDH1A1KMT2AATMADRB2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0852142-A1 | Diamines in the treatment of arrhythmia | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1998-07-08 | — | — | EP | disclosed |
| EP-0639973-A1 | DIAMINES IN THE TREATMENT OF ARRHYTHMIA | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1995-03-01 | — | — | EP | disclosed |
| WO-1993023024-A1 | DIAMINES IN THE TREATMENT OF ARRHYTHMIA | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1993-11-25 | — | — | WO | disclosed |