Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.64 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.63 |
| ▸ | APP | P05067 | 1/20 | 0.55 |
| ▸ | CTSV | O60911 | 1/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.51 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.51 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.51 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323568 | 0.82 | CYP3A4 (0.64) | NPC1RAB9AMTNR1AMTNR1BHDAC1 | |
| SCHEMBL7359187 | 0.82 | KMT2A (0.58) | NPC1RAB9AHDAC1HDAC2 | |
| SCHEMBL7355959 | 0.82 | HDAC1 (0.54) | NPC1RAB9AHDAC1HDAC2POLB | |
| SCHEMBL7335367 | 0.82 | NPC1 (0.55) | NPC1RAB9AHDAC1HDAC2POLB | |
| SCHEMBL7360125 | 0.82 | NPC1 (0.55) | NPC1RAB9AHDAC1HDAC2POLB | |
| SCHEMBL7326223 | 0.81 | NPC1 (0.54) | NPC1RAB9AHDAC1HDAC2 | |
| SCHEMBL7322931 | 0.80 | NPC1 (0.63) | NPC1RAB9AMTNR1AMTNR1BHDAC1 | |
| SCHEMBL5211526 | 0.79 | MTNR1A (0.82) | MTNR1AMTNR1BAPPPLAAT3PLAAT5 | |
| SCHEMBL7331861 | 0.77 | PLAAT3 (0.57) | MTNR1AMTNR1BHDAC1HDAC2PLAAT3 | |
| SCHEMBL18760165 | 0.77 | NPC1 (0.67) | NPC1RAB9AHDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0852142-A1 | Diamines in the treatment of arrhythmia | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1998-07-08 | — | — | EP | disclosed |
| EP-0639973-A1 | DIAMINES IN THE TREATMENT OF ARRHYTHMIA | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1995-03-01 | — | — | EP | disclosed |
| WO-1993023024-A1 | DIAMINES IN THE TREATMENT OF ARRHYTHMIA | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1993-11-25 | — | — | WO | disclosed |