Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 8/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 8/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370680 | 0.85 | MEN1 (0.44) | ADRB2ADRB1MEN1MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL7331358 | 0.85 | ADRB1 (0.58) | ADRB2ADRB1MEN1MAPTMAPK1 | |
| SCHEMBL7330491 | 0.83 | RAB9A (0.49) | ADRB2ADRB1MEN1MAPTMAPK1 | |
| SCHEMBL7332810 | 0.83 | MEN1 (0.45) | ADRB2ADRB1MEN1MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL7325518 | 0.82 | ADRB3 (0.56) | ADRB2ADRB1MEN1MAPTMAPK1 | |
| SCHEMBL7333244 | 0.82 | MEN1 (0.44) | ADRB2ADRB1MEN1MAPTMAPK1 | |
| SCHEMBL16550198 | 0.80 | ADRB2 (0.64) | ADRB2ADRB1MEN1MAPTMAPK1 | |
| SCHEMBL7329175 | 0.79 | KCNH2 (0.45) | ADRB2ADRB1MEN1MAPTMAPK1 | |
| SCHEMBL6649656 | 0.79 | MEN1 (0.57) | ADRB2ADRB1MEN1MAPTMAPK1 | |
| SCHEMBL7375804 | 0.78 | KDM4E (0.47) | ADRB2ADRB1MEN1KMT2AADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5385914-A | Cardiotonic carbostyril agents for treating heart ailments | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1995-01-31 | — | — | US | disclosed |
| EP-0355583-B1 | Cardiotonics | OTSUKA PHARMA CO LTD (JP) | 1995-01-25 | — | — | EP | disclosed |
| US-5266577-A | Method of treating congestive heart failure using carbostyril derivatives | OTSUKA PHARMACEUTICAL COMPANY LTD. (JP) | 1993-11-30 | — | — | US | disclosed |
| US-5198448-A | Cardiovascular disorders | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1993-03-30 | — | — | US | disclosed |
| US-5053514-A | Side effect reduction; carbostyril derivatives | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1991-10-01 | — | — | US | disclosed |
| EP-0355583-A2 | Cardiotonics | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-02-28 | — | — | EP | disclosed |