SCHEMBL7326345

SCHEMBL7326345

Cc1[nH]cnc1CC1COc2ccc3ccccc3c2C1=O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 1/20 0.47
HTR3A P46098 3/20 0.36
CYP3A4 P08684 2/20 0.36
CYP1A2 P05177 1/20 0.36
ADRA2C P18825 1/20 0.36
HTR2A P28223 1/20 0.36
HTR2C P28335 1/20 0.36
ADRA1A P35348 1/20 0.36
HTR2B P41595 1/20 0.36
KCNH2 Q12809 1/20 0.36
CASP6 P55212 1/20 0.36
GAA P10253 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
MAOB P27338 3/20 0.34
FFAR1 O14842 1/20 0.34
HTR3E A5X5Y0 1/20 0.32
HTR3B O95264 1/20 0.32
HTR3D Q70Z44 1/20 0.32
HTR3C Q8WXA8 1/20 0.32
ALDH1A1 P00352 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fumaric Acid SCHEMBL7332370 0.92 CYP19A1 (0.43) CYP19A1HTR3ACYP3A4CYP1A2ADRA2C
Maleic Acid SCHEMBL9787639 0.92 CYP19A1 (0.43) CYP19A1HTR3ACYP3A4CYP1A2ADRA2C
SCHEMBL8962746 0.81 HTR3A (0.39) CYP19A1HTR3ACYP3A4CYP1A2ADRA2C
Fumaric Acid SCHEMBL7437228 0.75 HTR3A (0.36) HTR3ACYP3A4CYP1A2ADRA2CHTR2A
Maleic Acid SCHEMBL7437214 0.75 HTR3A (0.36) HTR3ACYP3A4CYP1A2ADRA2CHTR2A
SCHEMBL7437223 0.72 HTR3A (0.36) HTR3ACYP3A4CYP1A2ADRA2CHTR2A
SCHEMBL7427595 0.70 HTR3A (0.38) CYP19A1HTR3ACYP3A4CYP1A2ADRA2C
SCHEMBL9597484 0.69 HTR3A (0.39) HTR3ACYP3A4CYP1A2ADRA2CHTR2A
SCHEMBL7430515 0.68 HTR3A (0.38) CYP19A1HTR3ACYP3A4CYP1A2ADRA2C
SCHEMBL9603272 0.68 HTR3A (0.36) HTR3ACYP3A4CYP1A2ADRA2CHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5006544-A 5-hydroxytryptamine antagonist for psychological and gastrointestinal disorders; anxiolytic agents GLAXO GROUP LIMITED (GB) 1991-04-09 US claimed
JP-2209876-A None JP disclosed
US-5006544-A 5-hydroxytryptamine antagonist for psychological and gastrointestinal disorders; anxiolytic agents GLAXO GROUP LIMITED (GB) 1991-04-09 US disclosed
JP-H02209876-A IMIDAZOLE DERIVATIVE GLAXO GROUP LTD 1990-08-21 JP disclosed
EP-0364274-A1 Imidazole derivatives GLAXO GROUP LIMITED (GB) 1990-04-18 EP disclosed