Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 2/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MITF | O75030 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10522151 | 0.82 | HTR3A (0.44) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL9597133 | 0.82 | PADI4 (0.34) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL9596051 | 0.80 | P2RX7 (0.34) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL9597476 | 0.79 | P2RX7 (0.32) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL9596742 | 0.78 | HTR3A (0.38) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL9597348 | 0.77 | HTR3A (0.36) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL9597678 | 0.77 | HTR3A (0.38) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL9596524 | 0.77 | HTR3A (0.36) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL9597198 | 0.77 | HTR3A (0.35) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL9597016 | 0.76 | HTR6 (0.36) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2049772-A | — | — | None | — | — | JP | disclosed |
| US-5116984-A | 5-hydroxytryptamine antagonists | GLAXO GROUP LIMITED (GB) | 1992-05-26 | — | — | US | disclosed |
| JP-H0249772-A | IMIDAZOLE DERIVATIVE | GLAXO GROUP LTD | 1990-02-20 | — | — | JP | disclosed |
| EP-0336759-A1 | Imidazole derivatives | GLAXO GROUP LIMITED (GB) | 1989-10-11 | — | — | EP | disclosed |