Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 5/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 5/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.37 |
| ▸ | CHAT | P28329 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28412294 | 0.83 | PTGER3 (0.39) | GABRA1GABRB2PTGER3PTGER2PTGER4 | |
| SCHEMBL6546259 | 0.83 | CHAT (0.47) | GABRA1GABRB2PTGER3PTGER2PTGER4 | |
| SCHEMBL3314625 | 0.83 | CHAT (0.47) | GABRA1GABRB2PTGER3PTGER2PTGER4 | |
| SCHEMBL17155197 | 0.80 | PTGER3 (0.37) | GABRA1GABRB2PTGER3PTGER2PTGER4 | |
| SCHEMBL5892736 | 0.79 | GABRA1 (0.43) | GABRA1GABRB2TSHRCYP2D6MGLL | |
| SCHEMBL5033527 | 0.77 | PDE5A (0.43) | PTGER3PTGER2PTGER4PTGER1TSHR | |
| SCHEMBL6546515 | 0.77 | MAOB (0.50) | PTGER3PTGER2PTGER4PTGER1CHAT | |
| SCHEMBL6546519 | 0.77 | MAOB (0.50) | PTGER3PTGER2PTGER4PTGER1CHAT | |
| SCHEMBL9494233 | 0.77 | CHAT (0.40) | GABRA1GABRB2PTGER3PTGER2PTGER4 | |
| SCHEMBL31094912 | 0.77 | CHAT (0.40) | GABRA1GABRB2PTGER3PTGER2PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347766-A2 | 4,5,7,8-Tetrahydro-6H-thiazolo[5,4-d]azepines, their preparation and their use as medicaments | Dr. Karl Thomae GmbH (DE) | 1989-12-27 | — | — | EP | disclosed |