Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.33 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18242067 | 0.84 | GABRA1 (0.42) | GABRA1GABRB2TSHRMGLLCYP2D6 | |
| SCHEMBL7326419 | 0.79 | GABRA1 (0.40) | GABRA1GABRB2TSHRMGLLCYP2D6 | |
| SCHEMBL5330754 | 0.78 | GABRA1 (0.38) | GABRA1GABRB2TSHRMGLLCYP2D6 | |
| SCHEMBL8371947 | 0.78 | GABRA1 (0.38) | GABRA1GABRB2TSHRMGLLCYP2D6 | |
| SCHEMBL1149697 | 0.77 | GABRA1 (0.37) | GABRA1GABRB2TSHRMGLLLMNA | |
| SCHEMBL1283641 | 0.77 | GABRA1 (0.44) | GABRA1GABRB2TSHRMGLLCYP2D6 | |
| SCHEMBL6546259 | 0.77 | CHAT (0.47) | GABRA1GABRB2TSHRMGLLLMNA | |
| SCHEMBL3314625 | 0.77 | CHAT (0.47) | GABRA1GABRB2TSHRMGLLLMNA | |
| SCHEMBL5832270 | 0.75 | GABRA1 (0.40) | GABRA1GABRB2MGLLLMNABLM | |
| SCHEMBL15563320 | 0.75 | POLB (0.37) | GABRA1GABRB2TSHRMGLLCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7030242-B2 | Selective inhibition of aggrecanase in osteoarthritis treatment | PFIZER INC (US) | 2006-04-18 | — | — | US | disclosed |