Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7326538 | 1.00 | SLC6A3 (0.35) | SLC6A3SLC6A2SLC6A4IDO1DHFR | |
| SCHEMBL7333402 | 0.94 | IDO1 (0.39) | SLC6A3SLC6A2SLC6A4IDO1DHFR | |
| SCHEMBL7333528 | 0.94 | IDO1 (0.36) | SLC6A3SLC6A2SLC6A4IDO1DHFR | |
| SCHEMBL7333523 | 0.94 | IDO1 (0.36) | SLC6A3SLC6A2SLC6A4IDO1DHFR | |
| SCHEMBL9719255 | 0.79 | PSEN1 (0.39) | SLC6A3SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL7355487 | 0.79 | PSEN1 (0.39) | SLC6A3SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL7355484 | 0.79 | PSEN1 (0.39) | SLC6A3SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL11774463 | 0.79 | PSEN1 (0.39) | SLC6A3SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL7328837 | 0.78 | NPC1 (0.33) | — | |
| SCHEMBL7325274 | 0.78 | NPC1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5198433-A | Hypotensive | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-03-30 | — | — | US | disclosed |
| US-5158945-A | Cardiotonic agents, vasodilators, hypotensive agents, anticonvulsants, antiisichemic agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-10-27 | — | — | US | disclosed |
| EP-0370320-B1 | LACTAMIMIDES IN THE TREATMENT OF DRUG-RESISTANT PROTOZOAL INFECTIONS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-09-30 | — | — | EP | disclosed |
| US-5128337-A | Hypotensive agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-07 | — | — | US | disclosed |
| US-5082837-A | Hypotensive | MERRELL DOW PHARMACEUTICALS (US) | 1992-01-21 | — | — | US | disclosed |
| US-5010072-A | Hypotensive agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-04-23 | — | — | US | disclosed |
| EP-0370320-A1 | Lactamimides in the treatment of drug-resistant protozoal infections | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-05-30 | — | — | EP | disclosed |
| EP-0348891-A2 | Lactamimides as calcium antagonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-01-03 | — | — | EP | disclosed |
| US-4061746-A | Lactamimide inhibitors of gastrointestinal hypersecretion | RICHARDSON-MERRELL INC. (US) | 1977-12-06 | — | — | US | disclosed |