Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.34 |
| ▸ | MLNR | O43193 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.32 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9719255 | 1.00 | PSEN1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL11774463 | 1.00 | PSEN1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7355487 | 1.00 | PSEN1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7335148 | 0.79 | HTR2A (0.40) | ALDH1A1HSD17B10SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7326534 | 0.79 | SLC6A3 (0.35) | ALDH1A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7326538 | 0.79 | SLC6A3 (0.35) | ALDH1A1SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL11745517 | 0.78 | HTR2A (0.39) | ALDH1A1HSD17B10SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL11741516 | 0.78 | HTR2A (0.39) | ALDH1A1HSD17B10SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7328244 | 0.77 | ALDH1A1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7328246 | 0.77 | ALDH1A1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5198433-A | Hypotensive | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-03-30 | — | — | US | disclosed |
| US-5158945-A | Cardiotonic agents, vasodilators, hypotensive agents, anticonvulsants, antiisichemic agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-10-27 | — | — | US | disclosed |
| US-5128337-A | Hypotensive agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-07 | — | — | US | disclosed |
| US-5082837-A | Hypotensive | MERRELL DOW PHARMACEUTICALS (US) | 1992-01-21 | — | — | US | disclosed |
| US-5010072-A | Hypotensive agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-04-23 | — | — | US | disclosed |
| EP-0370320-A1 | Lactamimides in the treatment of drug-resistant protozoal infections | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-05-30 | — | — | EP | disclosed |