Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HEXA | P06865 | 6/20 | 0.68 |
| ▸ | HEXB | P07686 | 6/20 | 0.68 |
| ▸ | OGA | O60502 | 1/20 | 0.68 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.56 |
| ▸ | AHR | P35869 | 1/20 | 0.56 |
| ▸ | RAD52 | P43351 | 1/20 | 0.56 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324978 | 0.90 | HEXA (0.67) | HEXAHEXBOGASIRT1KDM4E | |
| SCHEMBL1042197 | 0.83 | GLS (0.57) | MAPTSMN1; SMN2RAB9ACYP1A2 | |
| SCHEMBL30185439 | 0.83 | GLS (0.57) | MAPTSMN1; SMN2RAB9ACYP1A2 | |
| SCHEMBL7319904 | 0.82 | CYP1B1 (0.62) | HEXAHEXBOGASIRT1KDM4E | |
| SCHEMBL9626265 | 0.82 | HEXA (0.83) | HEXAHEXBOGASIRT1KDM4E | |
| SCHEMBL4408773 | 0.81 | HEXA (1.00) | HEXAHEXBOGASIRT1KDM4E | |
| SCHEMBL31011151 | 0.81 | HEXA (1.00) | HEXAHEXBOGASIRT1KDM4E | |
| SCHEMBL9625535 | 0.80 | HEXA (0.81) | HEXAHEXBOGASIRT1KDM4E | |
| SCHEMBL9625779 | 0.80 | HEXA (0.81) | HEXAHEXBOGASIRT1KDM4E | |
| SCHEMBL9625518 | 0.80 | HEXA (0.81) | HEXAHEXBOGASIRT1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995013817-A1 | ENDOTHELIN CONVERTING ENZYME INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-05-26 | — | — | WO | disclosed |
| EP-0612324-A1 | PHOSPHONOPEPTIDES WITH COLLAGENASE INHIBITING ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993009136-A1 | PHOSPHONOPEPTIDES WITH COLLAGENASE INHIBITING ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1993-05-13 | — | — | WO | disclosed |