SCHEMBL7327196

SCHEMBL7327196

NNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=NC1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OPRK1 P41145 7/20 0.48
PDE4D Q08499 3/20 0.48
CNR1 P21554 2/20 0.48
NTSR1 P30989 1/20 0.48
ALDH1A1 P00352 1/20 0.48
CHRM1 P11229 1/20 0.48
PKM P14618 1/20 0.48
HTT P42858 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
GABRA1 P14867 2/20 0.46
GABRA5 P31644 2/20 0.46
GABRA3 P34903 2/20 0.46
GABRA2 P47869 2/20 0.46
GABRB2 P47870 2/20 0.46
GABRP O00591 1/20 0.46
GABRD O14764 1/20 0.46
CACNA1F O60840 1/20 0.46
ALB P02768 1/20 0.46
GABRB1 P18505 1/20 0.46
GABRG2 P18507 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11039807 0.88 OPRK1 (0.49) OPRK1PDE4DCNR1NTSR1ALDH1A1
SCHEMBL5178956 0.87 OPRK1 (0.49) OPRK1PDE4DCNR1NTSR1ALDH1A1
SCHEMBL11385109 0.86 GABRA1 (0.49) OPRK1PDE4DGABRA1GABRA5GABRA3
SCHEMBL11610755 0.84 HTT (0.38) OPRK1PDE4DCNR1NTSR1ALDH1A1
SCHEMBL11107466 0.84 CHRM1 (0.48) ALDH1A1CHRM1GABRA1GABRA5GABRA3
SCHEMBL11653909 0.84 CHRM1 (0.48) OPRK1CNR1ALDH1A1CHRM1PKM
SCHEMBL11637935 0.84 LMNA (0.39) OPRK1ALDH1A1NPSR1GABRA1GABRA5
SCHEMBL11084467 0.84 OPRK1 (0.45) OPRK1PDE4DCNR1NTSR1ALDH1A1
SCHEMBL11610206 0.84 CHRM1 (0.51) OPRK1PDE4DCHRM1KCNH2LMNA
SCHEMBL11382448 0.83 IDO1 (0.47) OPRK1PDE4DCNR1NTSR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4107159-A Acetal hydrazones of 2-hydrazino-3H-1,4-benzodiazepine THE UPJOHN COMPANY (US) 1978-08-15 US claimed
EP-0219541-B1 TREATMENT OF PREMENSTRUAL SYNDROMES USING TRIAZOLOBENZODIAZEPINES THE UPJOHN COMPANY (US) 1989-09-20 EP disclosed
US-4689413-A Triazolo-benzodiazepine-1-ethanamines as diuretics THE UPJOHN COMPANY (US) 1987-08-25 US disclosed
EP-0219541-A1 TREATMENT OF PREMENSTRUAL SYNDROMES USING TRIAZOLOBENZODIAZEPINES. UPJOHN CO (US) 1987-04-29 EP disclosed
WO-1986006631-A2 TREATMENT OF PREMENSTRUAL SYNDROMES USING TRIAZOLOBENZODIAZEPINES THE UPJOHN COMPANY (US) 1986-11-20 WO disclosed
US-4514407-A HYPOTENSIVE AND ANTIEDEMIC AGENTS THE UPJOHN COMPANY (US) 1985-04-30 US disclosed
US-4250094-A SEDATIVES, TRANQUILIZERS, MUSCLE RELAXANTS, AND ANTIDEPRESSANTS THE UPJOHN COMPANY (US) 1981-02-10 US disclosed
US-4235775-A Triazolobenzodiazepine derivatives TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1980-11-25 US disclosed
US-4141902-A SEDATIVES, TRANQUILIZERS, MUSCLE RELAXANTS THE UPJOHN COMPANY (US) 1979-02-27 US disclosed
US-4116956-A BENZODIAZEPINE DERIVATIVES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1978-09-26 US disclosed
US-4086230-A 1,5-Dihydro-7-aryl-as-triazine[4,3,-α][1,4]benzodiazepin-1-ols THE UPJOHN COMPANY (US) 1978-04-25 US disclosed
US-4073784-A Certain as-triazino 4,3-a! 1,4!benzodiazepine-1,2-dione compounds THE UPJOHN COMPANY (US) 1978-02-14 US disclosed
US-4073785-A Certain as-triazino 4,3-a! 1,4!benzodiazepine derivatives THE UPJOHN COMPANY (US) 1978-02-14 US disclosed
US-4028356-A Triazinobenzodiazepines THE UPJOHN COMPANY (US) 1977-06-07 US disclosed
US-4021441-A 1-[(Allylamino)-methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines THE UPJOHN COMPANY (US) 1977-05-03 US disclosed
US-4017492-A As-triazinobenzodiazepin-1-ones THE UPJOHN COMPANY (US) 1977-04-12 US disclosed
US-4016165-A Triazino benzodiazepines THE UPJOHN COMPANY (US) 1977-04-05 US disclosed
US-4012413-A 1-(2-AMINOALKYL)-6-PHENYL-TRIAZOLO-BENZODIAZEPINE COMPOUNDS USED AS TRANQUILIZERS AND ANTIDEPRESSANTS THE UPJOHN COMPANY (US) 1977-03-15 US disclosed
US-4010177-A [3-Substituted-5-[(di-methylamino)methyl]-4H-1,2,4-triazol-4-yl]benzophenones and process THE UPJOHN COMPANY (US) 1977-03-01 US disclosed
US-3946032-A Acetal derivatives of 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxaldehyde CIBA-GEIGY CORPORATION (US) 1976-03-23 US disclosed