Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | FAAH | O00519 | 2/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23014378 | 0.85 | PLOD2 (0.57) | HDAC1HDAC8LMNAALDH1A1HDAC3 | |
| SCHEMBL552456 | 0.84 | HDAC1 (0.63) | HDAC1HDAC8LMNAHTTALDH1A1 | |
| SCHEMBL31030252 | 0.84 | HDAC1 (0.63) | HDAC1HDAC8LMNAHTTALDH1A1 | |
| SCHEMBL7327582 | 0.82 | ALDH1A1 (0.55) | HDAC1HDAC8HTTALDH1A1FAAH | |
| SCHEMBL7433203 | 0.81 | PLOD2 (0.51) | HDAC1HDAC8LMNAHTTALDH1A1 | |
| SCHEMBL552357 | 0.79 | HDAC1 (0.66) | HDAC1HDAC8LMNAHTTALDH1A1 | |
| SCHEMBL552045 | 0.78 | HDAC1 (0.68) | HDAC1HDAC8LMNAHTTALDH1A1 | |
| SCHEMBL9440256 | 0.78 | HDAC1 (0.68) | HDAC1HDAC8LMNAHTTALDH1A1 | |
| SCHEMBL551914 | 0.78 | HDAC1 (0.68) | HDAC1HDAC8LMNAHTTALDH1A1 | |
| SCHEMBL7021562 | 0.78 | EPHX2 (0.60) | HDAC1HDAC8FAAHKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369743-B1 | Heterocyclic amides | ZENECA LTD (GB) | 1995-04-19 | — | — | EP | disclosed |
| EP-0369743-A2 | Heterocyclic amides | ZENECA LIMITED (GB) | 1990-05-23 | — | — | EP | disclosed |