Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLOD2 | O00469 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.47 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | F7 | P08709 | 1/20 | 0.45 |
| ▸ | F3 | P13726 | 1/20 | 0.45 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.45 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.45 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9565319 | 0.83 | PLOD2 (0.46) | PLOD2THRBHDAC1HDAC8PLOD3 | |
| SCHEMBL9316752 | 0.82 | CYP1A2 (0.45) | PLOD2HDAC1PLOD3PLOD1HDAC3 | |
| SCHEMBL7439167 | 0.82 | PLOD2 (0.50) | PLOD2THRBHDAC1HDAC8PLOD3 | |
| SCHEMBL7327368 | 0.81 | HDAC1 (0.57) | PLOD2THRBHDAC1HDAC8HDAC3 | |
| SCHEMBL29350386 | 0.80 | PLOD2 (0.61) | PLOD2THRBHDAC1HDAC8PLOD3 | |
| SCHEMBL552724 | 0.80 | PLOD2 (0.61) | PLOD2THRBHDAC1HDAC8PLOD3 | |
| SCHEMBL23014378 | 0.80 | PLOD2 (0.57) | PLOD2THRBHDAC1HDAC8PLOD3 | |
| SCHEMBL7443990 | 0.80 | PLOD2 (0.57) | PLOD2THRBPLOD3PLOD1ALDH1A1 | |
| SCHEMBL5113226 | 0.80 | ALDH1A1 (0.52) | PLOD2THRBPLOD3PLOD1ALDH1A1 | |
| SCHEMBL7436954 | 0.79 | PLOD2 (0.53) | PLOD2THRBHDAC1HDAC8PLOD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5278161-A | Racemic mixtures | HOFFMANN-LA ROCHE INC. (US) | 1994-01-11 | — | — | US | disclosed |
| US-5091425-A | Inhibitors of the catalytic action of renin | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-02-25 | — | — | US | disclosed |
| EP-0464572-A2 | Aminoacid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1992-01-08 | — | — | EP | disclosed |