SCHEMBL7327451

SCHEMBL7327451

C=CN(C(=O)O)C(=O)c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKT1 P31749 1/20 0.48
ALDH1A1 P00352 3/20 0.41
TSHR P16473 3/20 0.41
CES2 O00748 2/20 0.41
CES1 P23141 2/20 0.41
DAO P14920 1/20 0.41
NAPRT Q6XQN6 1/20 0.41
TDP1 Q9NUW8 3/20 0.40
MAPK1 P28482 1/20 0.40
LMNA P02545 1/20 0.40
HSD11B1 P28845 2/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
HPGD P15428 1/20 0.39
RAB9A P51151 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
POLB P06746 1/20 0.38
CYP3A4 P08684 1/20 0.38
PARP1 P09874 1/20 0.38
MAPT P10636 1/20 0.38
CYP2C19 P33261 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20492517 0.91 AKT1 (0.52) AKT1ALDH1A1TSHRCES2CES1
SCHEMBL20492514 0.84 AKT1 (0.45) AKT1ALDH1A1TSHRCES2CES1
SCHEMBL6405803 0.78 AKT1 (0.52) AKT1ALDH1A1TSHRCES2CES1
SCHEMBL7315142 0.77 AKT1 (0.50) AKT1ALDH1A1TSHRCES2CES1
SCHEMBL6551303 0.76 HSD11B1 (0.51) AKT1ALDH1A1TSHRTDP1LMNA
SCHEMBL11583231 0.76 TDP1 (0.56) AKT1ALDH1A1TSHRCES2CES1
SCHEMBL2134534 0.75 AKT1 (0.48) AKT1ALDH1A1TSHRCES2CES1
SCHEMBL7313020 0.75 AKT1 (0.48) AKT1ALDH1A1TSHRCES2CES1
SCHEMBL5820979 0.73 AKT1 (0.47) AKT1ALDH1A1TSHRCES2CES1
SCHEMBL8415306 0.73 AKT1 (0.47) AKT1ALDH1A1TSHRCES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5583133-A ANTICOAGULANTS HOFFMANN-LA ROCHE INC. (US) 1996-12-10 US claimed
US-5532232-A INHIBIT THROMBIN INDUCED PLATELET AGGREGATION; FIBRINOGEN ANTICOAGULANTS IN BLOOD HOFFMANN-LA ROCHE INC. (US) 1996-07-02 US claimed
EP-0468231-B1 Guanidins HOFFMANN LA ROCHE (CH) 1994-09-21 EP claimed
US-5763436-A ANTICOAGULANTS HOFFMANN-LA ROCHE INC. (US) 1998-06-09 US disclosed
US-5595999-A ANTICOAGULANTS HOFFMANN-LA ROCHE INC. (US) 1997-01-21 US disclosed
US-5583133-A ANTICOAGULANTS HOFFMANN-LA ROCHE INC. (US) 1996-12-10 US disclosed
US-5532232-A INHIBIT THROMBIN INDUCED PLATELET AGGREGATION; FIBRINOGEN ANTICOAGULANTS IN BLOOD HOFFMANN-LA ROCHE INC. (US) 1996-07-02 US disclosed
US-5393760-A Cardiovascular disorders, antitumor agents HOFFMANN-LA ROCHE INC. (US) 1995-02-28 US disclosed
US-5260307-A Inhibit thrombin-induced platlet aggregation and clotting of fibrogen in plasma HOFMANN-LA ROCHE INC. (US) 1993-11-09 US disclosed