Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.36 |
| ▸ | PRKX | P51817 | 1/20 | 0.36 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.36 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 9/20 | 0.36 |
| ▸ | HTR1A | P08908 | 4/20 | 0.36 |
| ▸ | DRD2 | P14416 | 4/20 | 0.36 |
| ▸ | HTR2A | P28223 | 4/20 | 0.36 |
| ▸ | HTR7 | P34969 | 4/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7326979 | 0.93 | CHRM1 (0.43) | CHRM1ROCK2ROCK1PRKXPRKCE | |
| SCHEMBL7327003 | 0.87 | ROCK2 (0.36) | CHRM1ROCK2ROCK1PRKXPRKCE | |
| SCHEMBL7352432 | 0.74 | CHRM1 (0.56) | CHRM1ROCK2ROCK1PRKXPRKCE | |
| SCHEMBL4730348 | 0.74 | CHRM1 (0.53) | CHRM1ROCK2ROCK1PRKXPRKCE | |
| SCHEMBL7318271 | 0.73 | CHRM1 (0.55) | CHRM1ROCK2ROCK1PRKXPRKCE | |
| SCHEMBL7318880 | 0.72 | ROCK2 (0.49) | ROCK2ROCK1PRKXPRKCEPRKCD | |
| SCHEMBL7320739 | 0.72 | CHRM1 (0.40) | CHRM1ROCK2ROCK1PRKXPRKCE | |
| SCHEMBL4782353 | 0.72 | CHRM1 (0.52) | CHRM1ROCK2ROCK1PRKXPRKCE | |
| SCHEMBL7320742 | 0.71 | CHRM1 (0.42) | CHRM1ROCK2ROCK1PRKXPRKCE | |
| SCHEMBL7360633 | 0.71 | CHRM1 (0.38) | CHRM1ROCK2ROCK1PRKXPRKCE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287696-B1 | ISOQUINOLINE DERIVATIVES | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1991-01-02 | — | — | EP | disclosed |
| EP-0287696-A1 | Isoquinoline derivatives | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1988-10-26 | — | — | EP | disclosed |