Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 11/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 11/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 5/20 | 0.46 |
| ▸ | PRKCG | P05129 | 5/20 | 0.46 |
| ▸ | PRKCB | P05771 | 5/20 | 0.46 |
| ▸ | PRKCA | P17252 | 5/20 | 0.46 |
| ▸ | PRKCH | P24723 | 5/20 | 0.46 |
| ▸ | PRKCI | P41743 | 5/20 | 0.46 |
| ▸ | PRKCE | Q02156 | 5/20 | 0.46 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.46 |
| ▸ | PRKCZ | Q05513 | 5/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.46 |
| ▸ | PRKD1 | Q15139 | 5/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7327658 | 0.72 | CHRM1 (0.44) | ROCK2ROCK1JAK2JAK1TYK2 | |
| SCHEMBL7327003 | 0.72 | ROCK2 (0.36) | ROCK2ROCK1JAK2JAK1TYK2 | |
| SCHEMBL4728844 | 0.72 | ROCK2 (0.62) | ROCK2ROCK1CYP3A4PRKD3PRKCG | |
| SCHEMBL26555122 | 0.71 | ROCK2 (0.67) | ROCK2ROCK1CYP3A4PRKD3PRKCG | |
| SCHEMBL8828469 | 0.71 | PRKD3 (0.61) | ROCK2ROCK1CYP3A4PRKD3PRKCG | |
| Hydrochloric Acid SCHEMBL9194379 | 0.71 | ROCK2 (0.62) | ROCK2ROCK1CYP3A4PRKD3PRKCG | |
| SCHEMBL7327074 | 0.71 | ROCK2 (0.63) | ROCK2ROCK1CYP3A4PRKD3PRKCG | |
| SCHEMBL7315524 | 0.70 | CYP3A4 (0.62) | ROCK2ROCK1CYP3A4PRKD3PRKCG | |
| SCHEMBL190415 | 0.70 | ROCK2 (0.69) | ROCK2ROCK1CYP3A4PRKD3PRKCG | |
| SCHEMBL5083267 | 0.69 | ROCK2 (0.68) | ROCK2ROCK1CYP3A4PRKD3PRKCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287696-B1 | ISOQUINOLINE DERIVATIVES | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1991-01-02 | — | — | EP | disclosed |
| EP-0287696-A1 | Isoquinoline derivatives | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1988-10-26 | — | — | EP | disclosed |