Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | PRKX | P51817 | 1/20 | 0.32 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.32 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.32 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316964 | 0.88 | ROCK2 (0.33) | ROCK2ROCK1PRKXPRKCEPRKCD | |
| SCHEMBL7328994 | 0.76 | GAA (0.33) | ROCK2ROCK1LMNAPRKXPRKCE | |
| SCHEMBL7326979 | 0.75 | CHRM1 (0.43) | CHRM1ROCK2ROCK1LMNACYP3A4 | |
| SCHEMBL7320739 | 0.74 | CHRM1 (0.40) | CHRM1ROCK2ROCK1PRKXPRKCE | |
| SCHEMBL7323639 | 0.71 | CHRM1 (0.36) | CHRM1ROCK2ROCK1CYP3A4HTR6 | |
| SCHEMBL7327658 | 0.71 | CHRM1 (0.44) | CHRM1ROCK2ROCK1LMNACYP3A4 | |
| SCHEMBL7325032 | 0.69 | ROCK2 (0.36) | ROCK2ROCK1LMNAPRKXPRKCE | |
| SCHEMBL10019204 | 0.69 | LMNA (0.42) | CHRM1LMNACYP3A4MAPTAPEX1 | |
| SCHEMBL6994641 | 0.67 | CDK2 (0.53) | CHRM1ROCK2ROCK1LMNACYP3A4 | |
| SCHEMBL4730348 | 0.67 | CHRM1 (0.53) | CHRM1ROCK2ROCK1LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287696-B1 | ISOQUINOLINE DERIVATIVES | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1991-01-02 | — | — | EP | disclosed |
| EP-0287696-A1 | Isoquinoline derivatives | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1988-10-26 | — | — | EP | disclosed |