Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 4/20 | 0.59 |
| ▸ | PPARG | P37231 | 2/20 | 0.59 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | CTSL | P07711 | 2/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
| ▸ | TACR1 | P25103 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylalanine SCHEMBL7317243 | 0.89 | ALDH1A1 (0.59) | ITGB3ITGA2BALDH1A1ALOX15CTSL | |
| SCHEMBL7318941 | 0.87 | PPARA (0.66) | PPARAPPARGCTSLCTSBCTSS | |
| SCHEMBL7318257 | 0.86 | ALDH1A1 (0.65) | ITGB3ITGA2BALDH1A1ALOX15CTSL | |
| D-Phenylalanine SCHEMBL9445679 | 0.84 | ITGB3 (0.63) | ITGB3ITGA2BALDH1A1ALOX15CTSL | |
| SCHEMBL7322805 | 0.84 | ALDH1A1 (0.56) | ITGB3ITGA2BALDH1A1ALOX15CTSL | |
| Glycine SCHEMBL7316336 | 0.82 | ITGB3 (0.61) | ITGB3ITGA2BALDH1A1ALOX15CTSL | |
| SCHEMBL11185687 | 0.82 | PPARA (0.64) | PPARAPPARGITGB3ITGA2BCTSL | |
| SCHEMBL7326041 | 0.81 | CTSL (0.65) | ALDH1A1ALOX15CTSLCTSBCTSS | |
| SCHEMBL27533323 | 0.81 | PPARA (0.84) | PPARAPPARGCTSKTACR1 | |
| SCHEMBL1285732 | 0.81 | PPARA (0.84) | PPARAPPARGCTSKTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0272671-B1 | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors | SANDOZ LTD (CH) | 1994-03-16 | — | — | EP | disclosed |
| EP-0272671-A2 | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors | SANDOZ LTD. (CH) | 1988-06-29 | — | — | EP | disclosed |