Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 8/20 | 1.00 |
| ▸ | GABRA3 | P34903 | 9/20 | 0.72 |
| ▸ | GABRA1 | P14867 | 9/20 | 0.71 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7327402 | 0.91 | GABRA5 (0.82) | GABRA5GABRA3GABRA1GABRA2 | |
| SCHEMBL7333843 | 0.87 | GABRA3 (0.80) | GABRA5GABRA3GABRA1GABRA2 | |
| SCHEMBL7328404 | 0.87 | GABRA5 (0.77) | GABRA5GABRA3GABRA1GABRA2 | |
| SCHEMBL7335482 | 0.84 | GABRA1 (0.90) | GABRA5GABRA3GABRA1GABRA2 | |
| SCHEMBL7326033 | 0.84 | GABRA3 (1.00) | GABRA5GABRA3GABRA1GABRA2 | |
| SCHEMBL7330195 | 0.83 | GABRA3 (1.00) | GABRA5GABRA3GABRA1GABRA2 | |
| SCHEMBL7329893 | 0.82 | GABRA3 (0.86) | GABRA5GABRA3GABRA1GABRA2 | |
| SCHEMBL7329097 | 0.81 | GABRA1 (1.00) | GABRA5GABRA3GABRA1GABRA2 | |
| SCHEMBL7325998 | 0.81 | GABRA1 (0.86) | GABRA5GABRA3GABRA1GABRA2 | |
| SCHEMBL7329402 | 0.80 | GABRA3 (0.83) | GABRA5GABRA3GABRA1GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0536295-A1 | CERTAIN AZACYCLOALKYL IMIDAZOPYRIMIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1993-04-14 | — | — | EP | claimed |
| US-5095015-A | G-aminobutyric acid, anticonvulsants, tranquilizers, sleep disorders | NEUROGEN CORPORATION (US) | 1992-03-10 | — | — | US | claimed |
| WO-1992000296-A1 | CERTAIN AZACYCLOALKYL IMIDAZOPYRIMIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1992-01-09 | — | — | WO | claimed |
| US-5328912-A | Psychological disorders, cognition activators | NEUROGEN CORPORATION (US) | 1994-07-12 | — | — | US | disclosed |
| EP-0536295-A1 | CERTAIN AZACYCLOALKYL IMIDAZOPYRIMIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1993-04-14 | — | — | EP | disclosed |
| US-5095015-A | G-aminobutyric acid, anticonvulsants, tranquilizers, sleep disorders | NEUROGEN CORPORATION (US) | 1992-03-10 | — | — | US | disclosed |
| WO-1992000296-A1 | CERTAIN AZACYCLOALKYL IMIDAZOPYRIMIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1992-01-09 | — | — | WO | disclosed |